Evidence map›Paper›PMID 17029251›Full record

ArticleThe Journal of comparative neurology2006

Galpha encoding gene family of the malaria vector mosquito Anopheles gambiae: expression analysis and immunolocalization of AGalphaq and AGalphao in female antennae.

Michael Rützler, Tan Lu, Laurence J Zwiebel

Erratum issuedOpen access · greenAbstract readComparative Study
In one paragraph

Article in The Journal of comparative neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Tuning Insect Odorant Receptors.Frontiers in cellular neuroscience · 2018
    Article
  5. Article
  6. Article
  7. Brain proteomics of Anopheles gambiae.Omics : a journal of integrative biology · 2014
    Article
  8. Article
  9. Article
  10. Insect olfaction from model systems to disease control.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  11. Article
  12. Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael RützlerDepartment of Biological Sciences, Program in Developmental Biology, Centers for Molecular Neuroscience and Chemical Biology, Institute for Global Health, Vanderbilt University, Nashville, Tennessee 37235, USA.
Tan Lu
Laurence J Zwiebel
Vanderbilt University · US

Funding

Examination of Odorant Receptors in Vector MosquitoesR01AI056402 · NIAID · VANDERBILT UNIVERSITY · PI ZWIEBEL, LAURENCE J · 2003 to 2013
$4.0M
MOLECULAR GENETICS OF OLFACTION IN ANOPHELINE MOSQUITOESR01DC004692 · NIDCD · VANDERBILT UNIVERSITY · PI ZWIEBEL, LAURENCE J · 2000 to 2004
$1.1M
NIAID NIH HHS DC04692/AI56402NIAID NIH HHS R01 AI056402NIDCD NIH HHS R01 DC004692
6 · The paper itself

Abstract

To initiate a comprehensive investigation of chemosensory signal transduction downstream of odorant receptors, we identified and characterized the complete set of genes that encode G-protein alpha subunits in the genome of the malaria vector mosquito An. gambiae. Data are provided on the tissue-specific expression patterns of 10 corresponding aga-transcripts in adult mosquitoes and pre-imago developmental stages. Specific immunoreactivity in chemosensory hairs of female antennae provides evidence in support of the participation of a subset of AGalphaq isoforms in olfactory signal transduction in this mosquito. In contrast, AGalphao is localized along the flagellar axon bundle but is absent from chemosensory sensilla, which suggests that this G-protein alpha subunit does not participate in olfactory signal transduction.

Indexed as

Gene ExpressionAmino Acid SequenceAnimalsAnophelesBlotting, WesternBrainDrosophila melanogasterElectrophoresis, Polyacrylamide GelFemaleGene Expression ProfilingGTP-Binding Protein alpha SubunitsImmunohistochemistryIn Situ HybridizationMechanotransduction, CellularMolecular Sequence DataPhylogenyGTP-Binding Protein alpha SubunitsProtein IsoformsReceptors, Odorant

Identifiers

PMID17029251
PMCPMC3113460
OpenAlexW2081651326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.