ArticleCellular and molecular neurobiology
Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies.
Article in Cellular and molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 97 citations in OpenAlex.
- The impact on anxiety and perceived control of a short one-on-one nursing intervention designed to decrease treatment seeking delay in people with coronary heart disease.European journal of cardiovascular nursing · 2012Trial
- Brains, quacks, and boojums: a review of neurotransmitter and neuroendocrine bases of welfare and enrichment in poultry with an emphasis on the Pekin duck.Poultry science · 2026Review
- Serotonin Signaling through Lipid Membranes.ACS chemical neuroscience · 2024Review
- Anxiolytic, antioxidant, and neuroprotective effects of goji berry polysaccharides in ovariectomized rats: experimental evidence from behavioral, biochemical, and immunohistochemical analyses.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy in Rats.Frontiers in neuroscience · 2018Article
- Parental brain-derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents' warmth.Brain and behavior · 2017Article
- Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats.Molecular and cellular endocrinology · 2017Article
- Sex differences in brain-derived neurotrophic factor signaling and functions.Journal of neuroscience research · 2017Review
- Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters.Pharmacological reviews · 2016Review
- Article
- Sex differences in animal models of psychiatric disorders.British journal of pharmacology · 2014Review
- Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice.Psychopharmacology · 2014Article
- Early life stress inhibits expression of ribosomal RNA in the developing hippocampus.PloS one · 2014Article
- Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.Movement disorders : official journal of the Movement Disorder Society · 2013Article
- TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia.CNS & neurological disorders drug targets · 2013Article
- Voices from within: gut microbes and the CNS.Cellular and molecular life sciences : CMLS · 2013Review
- Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: implications for fetal programming.Developmental psychobiology · 2011Article
- Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity.Journal of abnormal psychology · 2011Article
- Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
1. Brain-derived neurotrophic factor (BDNF) supports serotonergic neuronal development and our recent study found that heterozygous mice lacking one BDNF gene allele interbred with male serotonin transporter (SERT) knockout mice had greater reductions in brain tissue serotonin concentrations, greater increases in anxiety-like behaviors and greater ACTH responses to stress than found in the SERT knockout mice alone. 2. We investigated here whether there might be gender differences in these consequences of combined SERT and BDNF deficiencies by extending the original studies to female mice, and also to an examination of the effects of ovariectomy and tamoxifen in these female mice, and of 21-day 17-beta estradiol implantation to male mice. 3. We found that unlike the male SERTxBDNF-deficient mice, female SERTxBDNF mice appeared protected by their gender in having significantly lesser reductions in serotonin concentrations in hypothalamus and other brain regions than males, relative to controls. Likewise, in the elevated plus maze, female SERTxBDNF-deficient mice demonstrated no increases in the anxiety-like behaviors previously found in males. 4. Furthermore, female SERTxBDNF mice did not manifest the approximately 40% reduction in the expression of TrkB receptors or the approximately 30% reductions in dopamine and its metabolites that male SERTxBDNF did. After estradiol implantation in male SERTxBDNF mice, hypothalamic serotonin was significantly increased compared to vehicle-implanted mice. These findings support the hypothesis that estrogen may enhance BDNF function via its TrkB receptor, leading to alterations in the serotonin circuits, which modulate anxiety-like behaviors. 5. This double-mutant mouse model contributes to the knowledge base that will help in understanding genexgenexgender interactions in studies of SERT and BDNF gene polymorphisms in human genetic diseases such as anxiety disorders and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.