ArticleClinical & experimental metastasis2006
Understanding metastatic SCCHN cells from unique genotypes to phenotypes with the aid of an animal model and DNA microarray analysis.
Article in Clinical & experimental metastasis, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Up-Regulation of Tiam1 Promotes the Radioresistance of Laryngeal Squamous Cell Carcinoma Through Activation of the JNK/ATF-2 Signaling Pathway.OncoTargets and therapy · 2020Article
- p70S6K promotes IL-6-induced epithelial-mesenchymal transition and metastasis of head and neck squamous cell carcinoma.Oncotarget · 2016Article
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- Inhibitors of NF-kappaB reverse cellular invasion and target gene upregulation in an experimental model of aggressive oral squamous cell carcinoma.Oral oncology · 2014Article
- Spectral-Spatial Classification Using Tensor Modeling for Cancer Detection with Hyperspectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2014Article
- Hyperspectral Imaging for Cancer Surgical Margin Delineation: Registration of Hyperspectral and Histological Images.Proceedings of SPIE--the International Society for Optical Engineering · 2014Article
- Spectral-spatial classification for noninvasive cancer detection using hyperspectral imaging.Journal of biomedical optics · 2014Article
- Quantitative iTRAQ LC-MS/MS Proteomics Reveals Transcription Factor Crosstalk and Regulatory Networks in Hypopharyngeal Squamous Cell Carcinoma.Journal of Cancer · 2014Article
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- Biodistribution Study of Nanoparticle Encapsulated Photodynamic Therapy Drugs Using Multispectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2013Article
- Epidermal growth factor promotes protein degradation of epithelial protein lost in neoplasm (EPLIN), a putative metastasis suppressor, during epithelial-mesenchymal transition.The Journal of biological chemistry · 2013Article
- The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Downregulation of EphA2 expression suppresses the growth and metastasis in squamous-cell carcinoma of the head and neck in vitro and in vivo.Journal of cancer research and clinical oncology · 2012Article
- K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr virus (EBV)--associated nasopharyngeal carcinoma cells.Investigational new drugs · 2012Article
- Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling.PloS one · 2010Article
- Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression.Molecular cancer research : MCR · 2010Article
- Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism.Molecular cancer therapeutics · 2009Article
- Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erlotinib and epigallocatechin-3-gallate: the role of p53-dependent inhibition of nuclear factor-kappaB.Cancer prevention research (Philadelphia, Pa.) · 2009Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis of squamous cell carcinoma of the head and neck (SCCHN) is a significant health-care problem worldwide. The 5-year survival rate is less than 50% for patients with lymph node metastases. Understanding the molecular basis of SCCHN metastasis would facilitate the development of new therapeutic approaches to the disease. To identify proteins that mediate SCCHN metastasis, we established a SCCHN xenograft mouse model and performed in vivo selection from a SCCHN cell line using the model. In the fourth round of in vivo selection, significant incidences of metastases in lymph nodes (7/10) and lungs (6/10) were achieved from a derived SCCHN cell line as compared with its parental cells, 1/5 in lymph nodes and 0/5 in lungs. Metastatic cell lines from lymph node metastases and parental cell lines from non-metastatic xenograft tumors were subjected to DNA microarray analysis using an Affymetrix gene chip HG-U133A, followed by data mining studies. The identified metastasis-related genes were further evaluated for their encoding protein products and the metastatic cells were examined by biological analyses. DNA microarray analysis highlighted molecular features of the metastatic SCCHN cells, including alteration of expression of cell-cell adhesion proteins, epithelial cell markers, apoptosis and cell cycle regulatory molecules. Further biological analyses of phenotypic alterations revealed that the metastatic cells gained epithelial-mesenchymal transition (EMT) features and were more resistant to anoikis, which are two of the important phenotypes for metastatic SCCHN.
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