ReviewNeuromolecular medicine2006
Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns.
Review in Neuromolecular medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 147 citations in OpenAlex.
- Incidence of and risk factors for neonatal jaundice among newborns in southern Nepal.Tropical medicine & international health : TM & IH · 2013Trial
- The Role of ER Stress in Bilirubin Neurotoxicity: A Complex Molecular Network.Antioxidants (Basel, Switzerland) · 2026Review
- The application of pre-discharge delta total bilirubin to predict the need for post-discharge phototherapy in healthy neonates 35 weeks' gestation or later.BMC pediatrics · 2025Article
- Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates.Scientific reports · 2025Article
- Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice.Cell death discovery · 2024Article
- Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.Nature communications · 2024Article
- Article
- Effects of Repetitive Transcranial Magnetic Stimulation on Pallidum GABAergic Neurons and Motor Function in Rat Models of Kernicterus.Brain sciences · 2023Article
- Effects of bilirubin on the development and electrical activity of neural circuits.Frontiers in cellular neuroscience · 2023Review
- Development and evaluation clinical-radiomics analysis based on T1-weighted imaging for diagnosing neonatal acute bilirubin encephalopathy.Frontiers in neurology · 2023Article
- Behavioural and emotional comorbidities in school-aged children with neurological conditions in Kilifi, Kenya, and their long-term consequences.Global health action · 2022Article
- Activation of Alternative Bilirubin Clearance Pathways Partially Reduces Hyperbilirubinemia in a Mouse Model Lacking Functional Ugt1a1 Activity.International journal of molecular sciences · 2022Article
- Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models.Cells · 2022Review
- Article
- Translational Approach to the Protective Effect of Bilirubin in Diabetic Kidney Disease.Biomedicines · 2022Review
- Exploring scraping therapy: Contemporary views on an ancient healing - A review.Journal of family medicine and primary care · 2021Review
- Choline supplementation prevents the effects of bilirubin on cerebellar-mediated behavior in choline-restricted Gunn rat pups.Pediatric research · 2021Article
- Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain.Current neuropharmacology · 2021Review
- Delayed Fulminant Hepatic Failure from Dydrogesterone-Related In Vitro Fertilization Therapy Requiring Liver Transplantation During Pregnancy.The American journal of case reports · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kernicterus is a devastating, chronic disabling neurological disorder whose central nervous system (CNS) sequelae reflect both a predilection of bilirubin toxicity for neurons (rather than glial cells) and the regional topography of bilirubin-induced neuronal injury that is characterized by prominent basal ganglia, cochlear, and oculomotor nuclei involvement. The molecular pathogenesis of bilirubin-induced neuronal cell injury, although incompletely understood, likely reflects the untoward effects of hazardous unconjugated bilirubin concentrations on plasma, mitochondrial, and/or endoplasmic reticulum (ER) membranes. These membrane perturbations, in turn, might lead to the genesis of neuronal excitotoxicity, mitochondrial energy failure, or increased intracellular calcium concentration [Ca2+]i. These three phenomena are likely to be linked spatially and temporally in the pathogenesis of bilirubin-induced neuronal injury. Downstream events triggered by increased [Ca2+]i may include, among others, the activation of proteolytic enzymes, apoptotic pathways, and/or necrosis, the individual occurrence of which is likely a function of the degree and duration of bilirubin exposure. A recent study demonstrates the activation of mitogen-activated protein kinase signal transduction pathways by bilirubin heralding a degree of complexity regarding the molecular mechanism(s) of bilirubin-induced neurotoxicity not previously appreciated. There remains, however, a paucity of data regarding specific effects of bilirubin on intracellular signaling and cell death pathways, particularly in vivo. An enhanced understanding of the molecular pathogenesis of bilirubin-induced neuronal injury will lead to the identification of potential novel interventional strategies to protect the CNS against kernicterus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.