ArticleGenetics2006
Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 89 citations in OpenAlex.
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- Genome-wide search algorithms for identifying dynamic gene co-expression via Bayesian variable selection.Statistics in medicine · 2023Article
- Epistasis for head morphology in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- The gut-microbiota-brain axis in autism: what Drosophila models can offer?Journal of neurodevelopmental disorders · 2021Review
- Genetic Basis of Natural Variation in Spontaneous Grooming inG3 (Bethesda, Md.) · 2020Article
- Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.Trends in genetics : TIG · 2020Review
- Evolution of Reproductive Behavior.Genetics · 2020Review
- F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol-Induced Behaviors in Drosophila.Alcoholism, clinical and experimental research · 2019Article
- The road less traveled: from genotype to phenotype in flies and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Sex-dependent expression of behavioural genetic architectures and the evolution of sexual dimorphism.Proceedings. Biological sciences · 2017Article
- A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure.PLoS genetics · 2017Article
- Article
- Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior.Genes, brain, and behavior · 2016Article
- Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.Parasites & vectors · 2015Article
- The genetic basis for variation in olfactory behavior in Drosophila melanogaster.Chemical senses · 2015Article
- Dissecting the Genetic Architecture of Behavior inCurrent opinion in behavioral sciences · 2015Article
- Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki).BMC bioinformatics · 2013Article
- Genetic architecture of olfactory behavior in Drosophila melanogaster: differences and similarities across development.Behavior genetics · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Understanding the genetic architecture of complex traits requires identification of the underlying genes and characterization of gene-by-gene and genotype-by-environment interactions. Behaviors that mediate interactions between organisms and their environment are complex traits expected to be especially sensitive to environmental conditions. Previous studies on the olfactory avoidance response of Drosophila melanogaster showed that the genetic architecture of this model behavior depends on epistatic networks of pleiotropic genes. We performed a screen of 1339 co-isogenic p[GT1]-element insertion lines to identify novel genes that contribute to odor-guided behavior and identified 55 candidate genes with known p[GT1]-element insertion sites. Characterization of the expression profiles of 10 p[GT1]-element insertion lines showed that the effects of the transposon insertions are often dependent on developmental stage and that hypomorphic mutations in developmental genes can elicit profound adult behavioral deficits. We assessed epistasis among these genes by constructing all possible double heterozygotes and measuring avoidance responses under two stimulus conditions. We observed enhancer and suppressor effects among subsets of these P-element-tagged genes, and surprisingly, epistatic interactions shifted with changes in the concentration of the olfactory stimulus. Our results show that the manifestation of epistatic networks dynamically changes with alterations in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.