ArticleGenetics2006
An Arabidopsis basic helix-loop-helix leucine zipper protein modulates metal homeostasis and auxin conjugate responsiveness.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 102 citations in OpenAlex.
- Novel Regulators and Their Epistatic Networks in Arabidopsis' Defence Responses to Alternaria alternata Infection.Molecular plant pathology · 2025Article
- AtIAR1 is a Zn transporter that regulates auxin metabolism in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Genome-wide transcript expression analysis reveals major chickpea and lentil genes associated with plant branching.Frontiers in plant science · 2024Article
- The Role of Iron in Phytopathogenic Microbe-Plant Interactions: Insights into Virulence and Host Immune Response.Plants (Basel, Switzerland) · 2023Review
- Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale.Scientific reports · 2022Article
- Primary nutrient sensors in plants.iScience · 2022Review
- Genome-Wide Characterization and Analysis of the bHLH Transcription Factor Family inFrontiers in genetics · 2022Article
- Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- IRON MAN interacts with BRUTUS to maintain iron homeostasis inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic architecture of root and shoot ionomes in rice (Oryza sativa L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- All together now: regulation of the iron deficiency response.Journal of experimental botany · 2021Review
- Further insights into the role of bHLH121 in the regulation of iron homeostasis inPlant signaling & behavior · 2020Article
- A curated list of genes that affect the plant ionome.Plant direct · 2020Article
- Iron homeostasis and plant immune responses: Recent insights and translational implications.The Journal of biological chemistry · 2020Review
- PRC2-mediated H3K27me3 modulates shoot iron homeostasis inPlant signaling & behavior · 2020Article
- The Role of Selective Protein Degradation in the Regulation of Iron and Sulfur Homeostasis in Plants.International journal of molecular sciences · 2020Review
- Genome-wide survey of the bHLH super gene family in Brassica napus.BMC plant biology · 2020Article
- The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.The Plant cell · 2020Article
- Iron deficiency triggered transcriptome changes in bread wheat.Computational and structural biotechnology journal · 2020Article
- Co-orthologues of ribosome biogenesis factors in A. thaliana are differentially regulated by transcription factors.Plant cell reports · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant hormone auxin can be regulated by formation and hydrolysis of amide-linked indole-3-acetic acid (IAA) conjugates. Here, we report the characterization of the dominant Arabidopsis iaa-leucine resistant3 (ilr3-1) mutant, which has reduced sensitivity to IAA-Leu and IAA-Phe, while retaining wild-type responses to free IAA. The gene defective in ilr3-1 encodes a basic helix-loop-helix leucine zipper protein, bHLH105, and the ilr3-1 lesion results in a truncated product. Overexpressing ilr3-1 in wild-type plants recapitulates certain ilr3-1 mutant phenotypes. In contrast, the loss-of-function ilr3-2 allele has increased IAA-Leu sensitivity compared to wild type, indicating that the ilr3-1 allele confers a gain of function. Microarray and quantitative real-time PCR analyses revealed five downregulated genes in ilr3-1, including three encoding putative membrane proteins similar to the yeast iron and manganese transporter Ccc1p. Transcript changes are accompanied by reciprocally misregulated metal accumulation in ilr3-1 and ilr3-2 mutants. Further, ilr3-1 seedlings are less sensitive than wild type to manganese, and auxin conjugate response phenotypes are dependent on exogenous metal concentration in ilr3 mutants. These data suggest a model in which the ILR3/bHLH105 transcription factor regulates expression of metal transporter genes, perhaps indirectly modulating IAA-conjugate hydrolysis by controlling the availability of metals previously shown to influence IAA-amino acid hydrolase protein activity.
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