ArticleGenetics2006
Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Herbal Ingredients in the Prevention of Breast Cancer: Comprehensive Review of Potential Molecular Targets and Role of Natural Products.Oxidative medicine and cellular longevity · 2022Review
- The developmental origins of Notch-driven intrahepatic bile duct disorders.Disease models & mechanisms · 2021Article
- Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications.Cellular oncology (Dordrecht, Netherlands) · 2021Review
- Article
- Notch-Mediated Cell Adhesion.Biology · 2016Review
- Notching on Cancer's Door: Notch Signaling in Brain Tumors.Frontiers in oncology · 2014Review
- Refining a Jagged edge.Structure (London, England : 1993) · 2013Article
- Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.The Journal of biological chemistry · 2013Article
- Notch inhibitors for cancer treatment.Pharmacology & therapeutics · 2013Review
- Delta-like 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma.International journal of oncology · 2013Article
- Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis.Developmental cell · 2012Article
- The role of endocytosis in activating and regulating signal transduction.Cellular and molecular life sciences : CMLS · 2012Review
- Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.Developmental biology · 2012Article
- Notch Signaling during Oogenesis in Drosophila melanogaster.Genetics research international · 2012Article
- Hedgehog, Patched and Dispatched near the basement.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The multiple roles of Notch signaling during left-right patterning.Cellular and molecular life sciences : CMLS · 2011Review
- Notch ligand ubiquitylation: what is it good for?Developmental cell · 2011Review
- Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling.Development (Cambridge, England) · 2011Article
- The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors.Acta histochemica · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The transmembrane proteins Delta and Notch act as ligand and receptor in a conserved signaling pathway required for a variety of cell fate specification events in many organisms. Binding of Delta to Notch results in a proteolytic cascade that releases the Notch intracellular domain, allowing it to participate in transcriptional activation in the nucleus. Recent research has implicated the endocytic and ubiquitylation machinery as essential components of Delta-Notch signaling. Our analysis of chimeric and missense Delta variants has delineated a number of structural requirements for Delta trafficking, receptor binding, and signaling. We find that while the Delta N-terminal domain is necessary and sufficient for binding to Notch, the integrity of the epidermal-growth-factor-like repeat (ELR) 2 is also required for Notch binding. Screening of 117 Delta mutant lines for proteins that exhibit aberrant subcellular trafficking has led to the identification of 18 Delta alleles (DlTD alleles) that encode "trafficking-defective" Delta proteins. We find, unexpectedly, that many DlTD alleles contain missense mutations in ELRs within the Delta extracellular domain. Finally, we find that two DlTD alleles contain lysine missense mutations within the Delta intracellular domain (DeltaICD) that may identify residues important for DeltaICD mono-ubiquitylation and subsequent Delta endocytosis and signaling.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.