ArticleGenetics2006
A point mutation in the Aspergillus nidulans sonBNup98 nuclear pore complex gene causes conditional DNA damage sensitivity.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- The Quest for the Blueprint of the Nuclear Pore Complex.The protein journal · 2019Review
- A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis.The Journal of clinical investigation · 2015Article
- Nuclear pore proteins and the control of genome functions.Genes & development · 2015Review
- Article
- Functional analysis of the Aspergillus nidulans kinome.PloS one · 2013Article
- The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells.Gastroenterology · 2011Article
- Functional characterization of a new member of the Cdk9 family in Aspergillus nidulans.Eukaryotic cell · 2010Article
- A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.Molecular cell · 2009Article
- Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.PLoS genetics · 2008Article
- Functional characterization of the putative Aspergillus nidulans DNA damage binding protein homologue DdbA.Molecular genetics and genomics : MGG · 2008Article
- Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.Molecular biology of the cell · 2007Article
- The spindle assembly checkpoint: More than just keeping track of the spindle.Trends in cell & molecular biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The nuclear pore complex (NPC) is embedded in the nuclear envelope where it mediates transport between the cytoplasm and nucleus and helps to organize nuclear architecture. We previously isolated sonB1, a mutation encoding a single amino acid substitution within the Aspergillus nidulans SONBnNup98 NPC protein (nucleoporin). Here we demonstrate that this mutation causes marked DNA damage sensitivity at 42 degrees . Although SONBnNup98 has roles in the G2 transition, we demonstrate that the G2 DNA damage checkpoint is functional in the sonB1 mutant at 42 degrees . The MRN complex is composed of MRE11, RAD50, and NBS1 and functions in checkpoint signaling, DNA repair, and telomere maintenance. At 42 degrees we find that the DNA damage response defect of sonB1 mutants causes synthetic lethality when combined with mutations in scaANBS1, the A. nidulans homolog of NBS1. We provide evidence that this synthetic lethality is independent of MRN cell cycle checkpoint functions or MREAMRE11-mediated DNA repair functions. We also demonstrate that the single A. nidulans histone H2A gene contains the C-terminal SQE motif of histone H2AX isoforms and that this motif is required for the DNA damage response. We propose that the sonB1 nucleoporin mutation causes a defect in a novel part of the DNA damage response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.