ArticleGenetics2006
Cis-regulatory evolution of chalcone-synthase expression in the genus Arabidopsis.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- WRKY33 negatively regulates anthocyanin biosynthesis and cooperates with PHR1 to mediate acclimation to phosphate starvation.Plant communications · 2024Article
- Multi-Omics Analyses Unravel Metabolic and Transcriptional Differences in Tender Shoots from TwoCurrent issues in molecular biology · 2023Article
- A computational investigation of cis-gene regulation in evolution.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity.Nature communications · 2021Article
- Plasticity of Mitochondrial DNA Inheritance and its Impact on Nuclear Gene Transcription in Yeast Hybrids.Microorganisms · 2020Article
- Bulk pollen sequencing reveals rapid evolution of segregation distortion in the male germline of Arabidopsis hybrids.Evolution letters · 2019Article
- Cis-regulatory variation in plant genomes and the impact of natural selection.American journal of botany · 2018Article
- Robustness of Transposable Element Regulation but No Genomic Shock Observed in Interspecific Arabidopsis Hybrids.Genome biology and evolution · 2018Article
- Stress-MediatedFrontiers in plant science · 2016Review
- Tempo and mode of regulatory evolution in Drosophila.Genome research · 2014Article
- Intertribal hybrid plants produced from crossing Arabidopsis thaliana with apomictic Boechera.Planta · 2012Article
- Article
- Allele-specific gene expression in a wild nonhuman primate population.Molecular ecology · 2011Article
- Variation in antiherbivore defense responses in synthetic Nicotiana allopolyploids correlates with changes in uniparental patterns of gene expression.Plant physiology · 2010Article
- Assessing the influence of adjacent gene orientation on the evolution of gene upstream regions in Arabidopsis thaliana.Genetics · 2010Article
- Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation.Molecular biology and evolution · 2009Article
- Article
- Article
- Differential expression of genes important for adaptation in Capsella bursa-pastoris (Brassicaceae).Plant physiology · 2007Article
- Mechanistic approaches to the study of evolution: the functional synthesis.Nature reviews. Genetics · 2007Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution of cis-regulation to adaptive evolutionary change is believed to be essential, yet little is known about the evolutionary rules that govern regulatory sequences. Here, we characterize the short-term evolutionary dynamics of a cis-regulatory region within and among two closely related species, A. lyrata and A. halleri, and compare our findings to A. thaliana. We focused on the cis-regulatory region of chalcone synthase (CHS), a key enzyme involved in the synthesis of plant secondary metabolites. We observed patterns of nucleotide diversity that differ among species but do not depart from neutral expectations. Using intra- and interspecific F1 progeny, we have evaluated functional cis-regulatory variation in response to light and herbivory, environmental cues, which are known to induce CHS expression. We find that substantial cis-regulatory variation segregates within and among populations as well as between species, some of which results from interspecific genetic introgression. We further demonstrate that, in A. thaliana, CHS cis-regulation in response to herbivory is greater than in A. lyrata or A. halleri. Our work indicates that the evolutionary dynamics of a cis-regulatory region is characterized by pervasive functional variation, achieved mostly by modification of response modules to one but not all environmental cues. Our study did not detect the footprint of selection on this variation.
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