ArticleGenetics2006
roX RNAs are required for increased expression of X-linked genes in Drosophila melanogaster males.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 93 citations in OpenAlex.
- Dosage compensation defects due to roX RNA loss are rescued by recalibration of X/autosome stoichiometry.Nucleic acids research · 2026Article
- roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity.EMBO reports · 2026Article
- The landscape and evolutionary dynamics of derived lncRNAs in insects.Communications biology · 2025Article
- A noncanonical role of roX RNAs in autosomal epigenetic repression.Nature communications · 2025Article
- siRNA that participates in Drosophila dosage compensation is produced by many 1.688X and 359 bp repeats.Genetics · 2024Article
- Review
- Emerging Roles of RNA-Binding Proteins in Neurodevelopment.Journal of developmental biology · 2022Review
- Review
- Correct dosage of X chromosome transcription is controlled by a nuclear pore component.Cell reports · 2021Article
- A functional requirement for sex-determination M/m locus region lncRNA genes in Aedes aegypti female larvae.Scientific reports · 2021Article
- Long Non-Coding RNAs in Insects.Animals : an open access journal from MDPI · 2021Review
- Mifepristone Increases Life Span of Virgin FemaleFrontiers in genetics · 2021Article
- Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution.Progress in molecular and subcellular biology · 2021Article
- Characterization and analysis of full-length transcriptomes from two grasshoppers, Gomphocerus licenti and Mongolotettix japonicus.Scientific reports · 2020Article
- Conserved chromosomal functions of RNA interference.Nature reviews. Genetics · 2020Review
- Article
- Functional Significance of Satellite DNAs: Insights FromFrontiers in cell and developmental biology · 2020Review
- Insights into the Functions of LncRNAs inInternational journal of molecular sciences · 2019Review
- Article
- RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.PLoS genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The male-specific lethal (MSL) ribonucleoprotein complex is necessary for equalization of X:A expression levels in Drosophila males, which have a single X chromosome. It binds selectively to the male X chromosome and directs acetylation of histone H4 at lysine 16 (H4Ac16), a modification linked to elevated transcription. roX1 and roX2 noncoding RNAs are essential but redundant components of this complex. Simultaneous removal of both roX RNAs reduces X localization of the MSL proteins and permits their ectopic binding to autosomal sites and the chromocenter. However, the MSL proteins still colocalize, and low levels of H4Ac16 are detected at ectopic sites of MSL binding and residual sites on the X chromosome of roX1- roX2- males. Microarray analysis was performed to reveal the effect of roX1 and roX2 elimination on X-linked and autosomal gene expression. Expression of the X chromosome is decreased by 26% in roX1- roX2- male larvae. Enhanced expression could not be detected at autosomal sites of MSL binding in roX1- roX2- males. These results implicate failure to compensate X-linked genes, rather than inappropriate upregulation of autosomal genes at ectopic sites of MSL binding, as the primary cause of male lethality upon loss of roX RNAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.