ArticleGenetics2007
An integrated in silico gene mapping strategy in inbred mice.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Evaluation and characterization of expression quantitative trait analysis methods in the Hybrid Rat Diversity Panel.Frontiers in genetics · 2022Article
- Article
- A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure.NPJ systems biology and applications · 2018Article
- Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice.PLoS genetics · 2017Article
- Heritability of periodontal bone loss in mice.Journal of periodontal research · 2015Article
- Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.PLoS genetics · 2013Article
- Genome-wide association studies in mice.Nature reviews. Genetics · 2012Review
- Emerging genetics of COPD.EMBO molecular medicine · 2012Review
- Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- In silico QTL mapping of maternal nurturing ability with the mouse diversity panel.Physiological genomics · 2012Article
- Haplotype Association Mapping Identifies a Candidate Gene Region in Mice Infected With Staphylococcus aureus.G3 (Bethesda, Md.) · 2012Article
- Quantitative trait Loci association mapping by imputation of strain origins in multifounder crosses.Genetics · 2012Article
- Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.Cancer research · 2011Article
- Fluoride's effects on the formation of teeth and bones, and the influence of genetics.Journal of dental research · 2011Review
- In silico QTL mapping of basal liver iron levels in inbred mouse strains.Physiological genomics · 2011Article
- Genome-wide association studies and genetic risk assessment of liver diseases.Nature reviews. Gastroenterology & hepatology · 2010Review
- Article
- A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci.Molecular genetics and genomics : MGG · 2010Article
- Assessing the prospects of genome-wide association studies performed in inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- A high-resolution association mapping panel for the dissection of complex traits in mice.Genome research · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years in silico analysis of common laboratory mice has been introduced and subsequently applied, in slightly different ways, as a methodology for gene mapping. Previously we have demonstrated some limitation of the methodology due to sporadic genetic correlations across the genome. Here, we revisit the three main aspects that affect in silico analysis. First, we report on the use of marker maps: we compared our existing 20,000 SNP map to the newly released 140,000 SNP map. Second, we investigated the effect of varying strain numbers on power to map QTL. Third, we introduced a novel statistical approach: a cladistic analysis, which is well suited for mouse genetics and has increased flexibility over existing in silico approaches. We have found that in our examples of complex traits, in silico analysis by itself does fail to uniquely identify quantitative trait gene (QTG)-containing regions. However, when combined with additional information, it may significantly help to prioritize candidate genes. We therefore recommend using an integrated work flow that uses other genomic information such as linkage regions, regions of shared ancestry, and gene expression information to obtain a list of candidate genes from the genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.