ArticleBiophysical journal2007
Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
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- The Force-Dependent Mechanism of an Integrin α4β7-MAdCAM-1 Interaction.International journal of molecular sciences · 2023Article
- Neutrophil-Dependent Immunity During Pulmonary Infections and Inflammations.Frontiers in immunology · 2021Review
- The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver.Frontiers in physiology · 2020Review
- Receptor-mediated cell mechanosensing.Molecular biology of the cell · 2017Review
- A Rough Energy Landscape to Describe Surface-Linked Antibody and Antigen Bond Formation.Scientific reports · 2016Article
- Flow-Enhanced Stability of Rolling Adhesion through E-Selectin.Biophysical journal · 2016Article
- Force and torque on spherical particles in micro-channel flows using computational fluid dynamics.Royal Society open science · 2016Article
- Non-affinity factors modulating vascular targeting of nano- and microcarriers.Advanced drug delivery reviews · 2016Review
- Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells.Stem cells international · 2016Article
- Transport regulation of two-dimensional receptor-ligand association.Biophysical journal · 2015Article
- Deconvoluting the ontogeny of hematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- The future of collateral artery research.Current cardiology reviews · 2014Review
- Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.The European physical journal. E, Soft matter · 2013Article
- Mechanical regulation of T-cell functions.Immunological reviews · 2013Review
- Rupture of single receptor-ligand bonds: a new insight into probability distribution function.Colloids and surfaces. B, Biointerfaces · 2013Article
- Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network.Immunological reviews · 2013Review
- Rupture of multiple receptor-ligand bonds: bimodal distribution of bond rupture force.The European physical journal. E, Soft matter · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Flow-enhanced cell adhesion is a counterintuitive phenomenon that has been observed in several biological systems. Flow augments L-selectin-dependent adhesion by increasing the initial tethering of leukocytes to vascular surfaces and by strengthening their subsequent rolling interactions. Tethering or rolling might be influenced by physical factors that affect the formation or dissociation of selectin-ligand bonds. We recently demonstrated that flow enhanced rolling of L-selectin-bearing microspheres or neutrophils on P-selectin glycoprotein ligand-1 by force decreased bond dissociation. Here, we show that flow augmented tethering of these microspheres or cells to P-selectin glycoprotein ligand-1 by three transport mechanisms that increased bond formation: sliding of the sphere bottom on the surface, Brownian motion, and molecular diffusion. These results elucidate the mechanisms for flow-enhanced tethering through L-selectin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.