ArticleMechanisms of ageing and development2006
Serum heat shock protein 70 level as a biomarker of exceptional longevity.
Article in Mechanisms of ageing and development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Chaperone Proteins: The Rising Players in Muscle Atrophy.Journal of cachexia, sarcopenia and muscle · 2025Review
- Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people.Journal of physiology and biochemistry · 2024Article
- Longevity, Centenarians and Modified Cellular Proteodynamics.International journal of molecular sciences · 2023Review
- A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases.Frontiers in aging neuroscience · 2020Article
- Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio.Cell stress & chaperones · 2017Article
- Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma.Mediators of inflammation · 2017Review
- Muscle heat shock protein 70 predicts insulin resistance with aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.Cell stress & chaperones · 2015Article
- ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age.Oncotarget · 2014Article
- A Drosophila ABC transporter regulates lifespan.PLoS genetics · 2014Article
- Association of heat shock proteins with all-cause mortality.Age (Dordrecht, Netherlands) · 2013Article
- Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring.Oxidative medicine and cellular longevity · 2013Article
- Heat shock proteins and Drosophila aging.Experimental gerontology · 2011Review
- Circulating heat shock protein 70 in health, aging and disease.BMC immunology · 2011Article
- Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy.Cell stress & chaperones · 2011Article
- Heat shock proteins as danger signals for cancer detection.Frontiers in oncology · 2011Article
- Power assessment for genetic association study of human longevity using offspring of long-lived subjects.European journal of epidemiology · 2010Article
- Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.Cell stress & chaperones · 2010Article
- Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Hsps and aging.Trends in endocrinology and metabolism: TEM · 2009Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Heat shock proteins are highly conserved proteins that, when produced intracellularly, protect stress exposed cells. In contrast, extracellular heat shock protein 70 (Hsp70) has been shown to have both protective and deleterious effects. In this study, we assessed heat shock protein 70 for its potential role in human longevity. Because of the importance of HSP to disease processes, cellular protection, and inflammation, we hypothesized that: (1) Hsp70 levels in centenarians and centenarian offspring are different from controls and (2) alleles in genes associated with Hsp70 explain these differences. In this cross-sectional study, we assessed serum Hsp70 levels from participants enrolled in either the New England Centenarian Study (NECS) or the Longevity Genes Project (LGP): 87 centenarians (from LGP), 93 centenarian offspring (from NECS), and 126 controls (43 from NECS, 83 from LGP). We also examined genotypic and allelic frequencies of polymorphisms in HSP70-A1A and HSP70-A1B in 347 centenarians (266 from the NECS, 81 from the LGP), 260 NECS centenarian offspring, and 238 controls (NECS: 53 spousal controls and 106 septuagenarian offspring controls; LGP: 79 spousal controls). The adjusted mean serum Hsp70 levels (ng/mL) for the NECS centenarian offspring, LGP centenarians, LGP spousal controls, and NECS controls were 1.05, 1.13, 3.07, 6.93, respectively, suggesting that a low serum Hsp70 level is associated with longevity; however, no genetic associations were found with two SNPs within two hsp70 genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.