Evidence map›Paper›PMID 17027618›Full record

ReviewPediatric clinics of North America2006

The cell biology of acute childhood respiratory disease: therapeutic implications.

Gerald M Loughlin, Anne Moscona

Abstract readReview
In one paragraph

Review in Pediatric clinics of North America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gerald M LoughlinDepartment of Pediatrics, Weill Medical College of Cornell University, 515 East 71st Street, New York, NY, USA.
Anne Moscona

Funding

Molecular basis for paramyxovirus entryR01AI031971 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCONA, ANNE · 1998 to 2016
$6.6M
Fusion triggering by Hendra virus F protein: role of GR21AI056185 · NIAID · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MOSCONA, ANNE · 2003 to 2004
$677k
Molecular basis for paramyxovirus entryR56AI031971 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCONA, ANNE · 2012 to 2012
$523k
MOLECULAR BASIS FOR PARAINFLUENZA 3 INFECTIONR29AI031971 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MOSCONA, ANNE · 1992 to 1996
–
NIAID NIH HHS AI056185NIAID NIH HHS AI31971NIAID NIH HHS R01 AI031971NIAID NIH HHS R21 AI056185NIAID NIH HHS R56 AI031971
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV), the recently identified human metapneumovirus (HMPV), and the human parainfluenza viruses (HPIVs), cause most cases of childhood croup, bronchiolitis, and pneumonia. Influenza virus also causes a significant burden of disease in young children, although its significance in children was not fully recognized until recently. This article discusses pathogens that have been studied for several decades, including RSV and HPIVs, and also explores the newly identified viral pathogens HMPV and human coronavirus NL63. The escalating rate of emergence of new infectious agents, fortunately meeting with equally rapid advancements in molecular methods of surveillance and pathogen discovery, means that new organisms will soon be added to the list. A section on therapies for bronchiolitis addresses the final common pathways that can result from infection with diverse pathogens, highlighting the mechanisms that may be amenable to therapeutic approaches. The article concludes with a discussion of the overarching impact of new diagnostic strategies.

Indexed as

Acute DiseaseChild, PreschoolHumansImmunizationInfantInfant, NewbornRespiratory Tract Infections

Identifiers

PMID17027618
PMCPMC7111702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.