ArticleImmunology1990
Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins.
Article in Immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications.International journal of molecular sciences · 2020Review
- The Immunomodulatory Properties of Amniotic Cells: The Two Sides of the Coin.Cell transplantation · 2018Article
- Both freshly prepared and frozen-stored amniotic membrane cells express the complement inhibitor CD59.TheScientificWorldJournal · 2012Article
- Amnion-derived stem cells: in quest of clinical applications.Stem cell research & therapy · 2011Review
- Membrane proteins that protect against complement lysis.Springer seminars in immunopathology · 1994Review
- Complement in human reproduction: activation and control.Immunologic research · 1993Review
- Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid.Immunology · 1992Article
- Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes.The Biochemical journal · 1992Article
- Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells.Immunology · 1992Article
- Amniotic epithelial cells enhance islet engraftment by suppressing early inflammation in intraportal transplantation.Cell transplantationArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cultured human amniotic epithelial cells (HAEC) were found by immunofluorescence microscopy to express three complement inhibitory membrane proteins, CD59 antigen, decay-accelerating factor (DAF) and membrane attack complex (MAC) inhibitory protein (MIP), on their surfaces. The effects of incubation with Fab2 fragments of monoclonal antibodies (mAb) raised against these proteins on susceptibility of sensitized cells to lysis by homologous complement was examined. Percentage cell lysis was markedly increased in the presence of Fab2 anti-CD59 and to a lesser, but significant, extent in the presence of Fab2 anti-DAF. Fab2 anti-MIP did not alter the sensitivity of the cells to lysis by complement.
Indexed as
Identifiers
1702747PMC1384423W1555316472What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.