ArticleBMC genetics2006
Dog Y chromosomal DNA sequence: identification, sequencing and SNP discovery.
Article in BMC genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Article
- The evolutionary history of grey wolf Y chromosomes.Molecular ecology · 2019Article
- Novel Y Chromosome Retrocopies in Canids Revealed through a Genome-Wide Association Study for Sex.Genes · 2019Article
- Analysis of the canid Y-chromosome phylogeny using short-read sequencing data reveals the presence of distinct haplogroups among Neolithic European dogs.BMC genomics · 2018Article
- Y-chromosome polymorphisms of the domestic Bactrian camel in China.Journal of genetics · 2018Article
- Conservation implications for dingoes from the maternal and paternal genome: Multiple populations, dog introgression, and demography.Ecology and evolution · 2017Article
- Y-Chromosome Markers for the Red Fox.The Journal of heredity · 2017Article
- New insights into the genetic composition and phylogenetic relationship of wolves and dogs in the Iberian Peninsula.Ecology and evolution · 2017Article
- Review
- Questioning the evidence for a Central Asian domestication origin of dogs.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Reply to Wang et al.: Sequencing datasets do not refute Central Asian domestication origin of dogs.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Identification of genetic variation on the horse y chromosome and the tracing of male founder lineages in modern breeds.PloS one · 2013Article
- Origins of domestic dog in southern East Asia is supported by analysis of Y-chromosome DNA.Heredity · 2012Article
- Mitochondrial DNA data indicate an introduction through Mainland Southeast Asia for Australian dingoes and Polynesian domestic dogs.Proceedings. Biological sciences · 2012Article
- Narrow genetic basis for the Australian dingo confirmed through analysis of paternal ancestry.Genetica · 2012Article
- Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping.PLoS genetics · 2011Article
- Discovery of lost diversity of paternal horse lineages using ancient DNA.Nature communications · 2011Article
- Phylogenetic distinctiveness of Middle Eastern and Southeast Asian village dog Y chromosomes illuminates dog origins.PloS one · 2011Article
- mtDNA data indicate a single origin for dogs south of Yangtze River, less than 16,300 years ago, from numerous wolves.Molecular biology and evolution · 2009Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation genetic studies of dogs have so far mainly been based on analysis of mitochondrial DNA, describing only the history of female dogs. To get a picture of the male history, as well as a second independent marker, there is a need for studies of biallelic Y-chromosome polymorphisms. However, there are no biallelic polymorphisms reported, and only 3200 bp of non-repetitive dog Y-chromosome sequence deposited in GenBank, necessitating the identification of dog Y chromosome sequence and the search for polymorphisms therein. The genome has been only partially sequenced for one male dog, disallowing mapping of the sequence into specific chromosomes. However, by comparing the male genome sequence to the complete female dog genome sequence, candidate Y-chromosome sequence may be identified by exclusion.
resultsThe male dog genome sequence was analysed by Blast search against the human genome to identify sequences with a best match to the human Y chromosome and to the female dog genome to identify those absent in the female genome. Candidate sequences were then tested for male specificity by PCR of five male and five female dogs. 32 sequences from the male genome, with a total length of 24 kbp, were identified as male specific, based on a match to the human Y chromosome, absence in the female dog genome and male specific PCR results. 14437 bp were then sequenced for 10 male dogs originating from Europe, Southwest Asia, Siberia, East Asia, Africa and America. Nine haplotypes were found, which were defined by 14 substitutions. The genetic distance between the haplotypes indicates that they originate from at least five wolf haplotypes. There was no obvious trend in the geographic distribution of the haplotypes.
conclusionWe have identified 24159 bp of dog Y-chromosome sequence to be used for population genetic studies. We sequenced 14437 bp in a worldwide collection of dogs, identifying 14 SNPs for future SNP analyses, and giving a first description of the dog Y-chromosome phylogeny.
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