ArticleBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy2006
Spotlight on darbepoetin alfa in the treatment of anemia in patients with cancer receiving chemotherapy.
Article in BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 1 citations in OpenAlex.
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2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Darbepoetin alfa (Aranesp) is an analog of recombinant human erythropoietin (rHuEPO) produced using recombinant DNA technology. The high number of sialic acid moieties in darbepoetin alfa results in a prolonged half-life and enhanced in vivo biologic activity compared with rHuEPO (as demonstrated in animal studies), and permits a reduction in the frequency of administration. Subcutaneous darbepoetin alfa 2.25 microg/kg once weekly or 500microg once every 3 weeks (with a provision for dosage adjustments) is an effective and well tolerated erythropoietic agent in anemic patients with cancer receiving chemotherapy. In randomized, controlled clinical trials, the drug increased hemoglobin levels and reduced the need for blood transfusions in patients with various types of nonmyeloid malignancies, and also ameliorated anemia-related fatigue, thereby improving their health-related quality of life scores. The once-every-3-weeks dosage regimen provides further convenience by offering the possibility of synchronizing its administration with most chemotherapy regimens. Direct comparisons between approved dosages of darbepoetin alfa and other erythropoietic agents have not been conducted. Such comparisons would be very helpful in formulating definitive conclusions about their relative efficacy and cost effectiveness. Darbepoetin alfa provides an effective and well tolerated treatment option for the treatment of anemia in patients with cancer receiving chemotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.