ReviewThe AAPS journal2006
Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence.
Review in The AAPS journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2023Article
- Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels.Human molecular genetics · 2020Article
- Agmatine preferentially antagonizes GluN2B-containing N-methyl-d-aspartate receptors in spinal cord.Journal of neurophysiology · 2019Article
- Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy.Journal of experimental pharmacology · 2018Review
- Combined Interactions with IACS medicinal chemistry letters · 2016Article
- Retroviral expression of human arginine decarboxylase reduces oxidative stress injury in mouse cortical astrocytes.BMC neuroscience · 2014Article
- Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation.Brain research · 2011Article
- Article
- Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Agmatine and imidazoline receptors: their role in opioid analgesia, tolerance and dependence.Cellular and molecular neurobiology · 2008Review
- Article
- Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain.Molecular painArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator. In animal studies, agmatine potentiated morphine analgesia and reduced dependence/withdrawal. While the exact mechanism is not clear, the interactions with N-methyl-D-aspartate (NMDA) receptors, alpha2-adrenergic receptors, and intracellular cyclic adenosine monophosphate (cAMP) signaling have been proposed as possible targets. Like other monoamine transmitter molecules, agmatine is rapidly metabolized in the periphery and has poor penetration into the brain, which limits the use of agmatine itself as a therapeutic agent. However, the development of agmatinase inhibitors will offer a useful method to increase endogenous agmatine in the brain as a possible therapeutic approach to potentiate morphine analgesia and reduce dependence/withdrawal. This review provides a succinct discussion of the biological role/therapeutic potential of agmatine during morphine exposure/pain modulation, with an extensive amount of literature cited for further details.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.