ArticleHistochemistry and cell biology2007
Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts.
Article in Histochemistry and cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Isolation of Lung Retinoid-Containing Cells by Cell Sorting.Journal of visualized experiments : JoVE · 2025Article
- Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis.eLife · 2024Article
- Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice.Nature communications · 2023Article
- Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway.Cellular and molecular life sciences : CMLS · 2022Article
- Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis.Frontiers in pharmacology · 2021Article
- The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis.Differentiation; research in biological diversity · 2016Review
- Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Culture Model of Rat Portal Myofibroblasts.Frontiers in physiology · 2016Article
- Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts.Frontiers in physiology · 2015Review
- Isolation and time lapse microscopy of highly pure hepatic stellate cells.Analytical cellular pathology (Amsterdam) · 2015Article
- Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Hepatic stellate cells function as regulatory bystanders.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Paediatric cholestatic liver disease: Diagnosis, assessment of disease progression and mechanisms of fibrogenesis.World journal of gastrointestinal pathophysiology · 2010Article
- Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.Hepatology (Baltimore, Md.) · 2009Article
- Thy-1 is expressed in myofibroblasts but not found in hepatic stellate cells following liver injury.Histochemistry and cell biology · 2009Article
- Recent progress in histochemistry.Histochemistry and cell biology · 2007Review
- The myofibroblast: one function, multiple origins.The American journal of pathology · 2007Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myofibroblasts (MFs) as well as hepatic stellate cells (HSCs) are known to be involved in liver fibrogenesis. Quiescent HSCs (qHSCs) in culture have been thought to differentiate to replicative activated HSCs (aHSCs). In this study a qHSC-enriched fraction isolated by Nycodenz-isodensity centrifugation was separated with a fluorescence-activated cell sorter, which revealed the presence of a small fraction (occupancy rate=0.4%) of cells that did not show vitamin A-autofluorescence under ultraviolet (UV)-irradiation (UV- cells). The remaining vitamin A-containing cells were autofluorescent (UV+) and originally expressed markers of qHSCs, and, in culture, did not grow, lost vitamin A, and expressed markers of aHSCs. UV- cells showed morphology of MFs, and, in culture, grew to form colonies and expressed markers of MFs. These results indicated that UV+ and UV- cells represent qHSCs and MFs, respectively, and that aHSCs have no growth potential and are a cell-type distinct from proliferative MFs. Gene expression profiles of UV- cells (MFs) newly identified gremlin as one of MF-preferential genes and its proteins were localized around fibrotic septa in rat and human livers. In addition, we suggested that the qHSC-enriched fraction included approximately 6% of liver MFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.