ArticleNeurogenetics2007
Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes.
Article in Neurogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Article
- Mining Complex Genetic Patterns Conferring Multiple Sclerosis Risk.International journal of environmental research and public health · 2021Article
- Genetic and environmental risk for lymphoma in boxer dogs.Journal of veterinary internal medicine · 2020Article
- Evaluation of ICAM-1 and VCAM-1 Gene Polymorphisms in Patients with Periodontal Disease.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Interaction among nitric oxide (NO)-related genes in migraine susceptibility.Molecular and cellular biochemistry · 2012Article
- Review
- A comparison of multifactor dimensionality reduction and L1-penalized regression to identify gene-gene interactions in genetic association studies.Statistical applications in genetics and molecular biology · 2011Article
- The effect of retrospective sampling on estimates of prediction error for multifactor dimensionality reduction.Annals of human genetics · 2011Article
- A comparison of internal validation techniques for multifactor dimensionality reduction.BMC bioinformatics · 2010Article
- Lack of Association between Glutathione S-Transferase-M1, -T1, and -P1 Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients.Psychiatry investigation · 2010Article
- Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.Human genetics · 2010Article
- Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.BMC bioinformatics · 2008Article
- In utero environmental tobacco smoke exposure alters gene expression in lungs of adult BALB/c mice.Environmental health perspectives · 2007Article
- Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis.Frontiers in integrative neuroscience · 2007Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The complex inheritance involved in multiple sclerosis (MS) risk has been extensively investigated, but our understanding of MS genetics remains rudimentary. In this study, we explore 51 single nucleotide polymorphisms (SNPs) in 36 candidate genes from the inflammatory pathway and test for gene-gene interactions using complementary case-control, discordant sibling pair, and trio family study designs. We used a sample of 421 carefully diagnosed MS cases and 96 unrelated, healthy controls; discordant sibling pairs from 146 multiplex families; and 275 trio families. We used multifactor dimensionality reduction to explore gene-gene interactions. Based on our analyses, we have identified several statistically significant models including both main effect models and two-locus, three-locus, and four-locus epistasis models that predict MS disease risk with between approximately 61% and 85% accuracy. These results suggest that significant epistasis, or gene-gene interactions, may exist even in the absence of statistically significant individual main effects.
Indexed as
Identifiers
17024427What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.