ArticleHuman genetics2007
Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.European journal of human genetics : EJHG · 2010Pooled it
- FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies.Human molecular genetics · 2023Article
- Adult allergic rhinitis sufferers have unique nasal mucosal and peripheral blood immune gene expression profiles: A case-control study.Immunity, inflammation and disease · 2022Article
- Consistent Biomarkers and Related Pathogenesis Underlying Asthma Revealed by Systems Biology Approach.International journal of molecular sciences · 2019Article
- An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.Chest · 2018Article
- Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.Pharmacogenetics and genomics · 2013Article
- P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.American journal of respiratory and critical care medicine · 2013Article
- Article
- Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2011Article
- PRKCA: a positional candidate gene for body mass index and asthma.American journal of human genetics · 2009Article
- Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource.European journal of human genetics : EJHG · 2009Article
- A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12.Genetic epidemiology · 2009Article
- Linkage analysis with dense SNP maps in isolated populations.Human heredity · 2009Article
- Standardized method to minimize variability in a functional P2X(7) flow cytometric assay for a multi-center clinical trial.Cytometry. Part B, Clinical cytometry · 2008Article
- Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases.Translational research : the journal of laboratory and clinical medicine · 2008Review
- Genomics and proteomics of lung disease: conference summary.American journal of physiology. Lung cellular and molecular physiology · 2007Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 4 countries.
Funding
Abstract
Although asthma is a major public health problem in certain Hispanic subgroups in the United States and Latin America, only one genome scan for asthma has included Hispanic individuals. Because of small sample size, that study had limited statistical power to detect linkage to asthma and its intermediate phenotypes in Hispanic participants. To identify genomic regions that contain susceptibility genes for asthma and airway responsiveness in an isolated Hispanic population living in the Central Valley of Costa Rica, we conducted a genome-wide linkage analysis of asthma (n = 638) and airway responsiveness (n = 488) in members of eight large pedigrees of Costa Rican children with asthma. Nonparametric multipoint linkage analysis of asthma was conducted by the NPL-PAIR allele-sharing statistic, and variance component models were used for the multipoint linkage analysis of airway responsiveness as a quantitative phenotype. All linkage analyses were repeated after exclusion of the phenotypic data of former and current smokers. Chromosome 12q showed some evidence of linkage to asthma, particularly in nonsmokers (P < 0.01). Among nonsmokers, there was suggestive evidence of linkage to airway responsiveness on chromosome 12q24.31 (LOD = 2.33 at 146 cM). After genotyping 18 additional short-tandem repeat markers on chromosome 12q, there was significant evidence of linkage to airway responsiveness on chromosome 12q24.31 (LOD = 3.79 at 144 cM), with a relatively narrow 1.5-LOD unit support interval for the observed linkage peak (142-147 cM). Our results suggest that chromosome 12q24.31 contains a locus (or loci) that influence a critical intermediate phenotype of asthma (airway responsiveness) in Costa Ricans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.