ArticleJournal of neural transmission (Vienna, Austria : 1996)2007
Voxel-based morphometry indicates relative preservation of the limbic prefrontal cortex in early Huntington disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Consistent neurodegeneration and its association with clinical progression in Huntington's disease: a coordinate-based meta-analysis.Neuro-degenerative diseases · 2013Pooled it
- Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review.Frontiers in neurology · 2021Review
- Time will tell: Decision making in premanifest and manifest Huntington's disease.Brain and behavior · 2020Article
- White and Gray Matter Abnormalities in Manifest Huntington's Disease: Cross-Sectional and Longitudinal Analysis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes.NeuroImage. Clinical · 2020Article
- The Role of Hypothalamic Pathology for Non-Motor Features of Huntington's Disease.Journal of Huntington's disease · 2019Review
- Progressive microstructural changes of the occipital cortex in Huntington's disease.Brain imaging and behavior · 2018Article
- Disrupted striatal neuron inputs and outputs in Huntington's disease.CNS neuroscience & therapeutics · 2018Review
- The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study.Brain and behavior · 2015Article
- Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.Frontiers in systems neuroscience · 2014Article
- Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.Neurobiology of disease · 2013Article
- EEG low-resolution brain electromagnetic tomography (LORETA) in Huntington's disease.Journal of neurology · 2011Article
- Genetics and neuropathology of Huntington's disease.International review of neurobiology · 2011Review
- Cerebral cortex structure in prodromal Huntington disease.Neurobiology of disease · 2010Article
- Magnetization transfer MR imaging demonstrates degeneration of the subcortical and cortical gray matter in Huntington disease.AJNR. American journal of neuroradiology · 2010Article
- Regional distribution and clinical correlates of white matter structural damage in Huntington disease: a tract-based spatial statistics study.AJNR. American journal of neuroradiology · 2010Article
- How vital is sleep in Huntington's disease?Journal of neurology · 2010Review
- Striatal and white matter predictors of estimated diagnosis for Huntington disease.Brain research bulletin · 2010Article
- Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease.AJNR. American journal of neuroradiology · 2010Article
- Magnetic resonance imaging of Huntington's disease: preparing for clinical trials.Neuroscience · 2009Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Huntington disease (HD), both the genetic defect and mutant gene product huntington are known but the exact mechanisms that lead to neuronal loss are poorly understood. Until now, the distribution of tissue loss throughout the brain has been investigated intensively. Here we searched for areas that, antipodal to the striatum, display grey-matter (GM) preservation. We performed high resolution T1-weighted magnetic resonance imaging and voxel-based morphometry in 46 patients in early HD and 46 healthy controls. We applied an analysis of covariance (ANCOVA) model with the total GM volume of each participant as covariate. In accordance with earlier reports, group comparisons revealed GM decrease in the striatum, insula, and thalamus as well as in dorsolateral frontal and occipital areas. In contrast, the limbic prefrontal cortex displayed GM preservation. Our findings support hypotheses that postulate differential involvement of frontosubcortical circuits in the pathophysiology of HD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.