ArticleThe EMBO journal2006
Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Structural basis of menaquinone reduction by succinate dehydrogenase from Chloroflexus aurantiacus.Nature communications · 2025Article
- Functionality of the NaArchives of microbiology · 2023Article
- A Sodium-Translocating Module Linking Succinate Production to Formation of Membrane Potential in Prevotella bryantii.Applied and environmental microbiology · 2021Article
- Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF.Nature communications · 2020Article
- X-ray structure of the direct electron transfer-type FAD glucose dehydrogenase catalytic subunit complexed with a hitchhiker protein.Acta crystallographica. Section D, Structural biology · 2019Article
- Direct Electron Transfer of Enzymes Facilitated by Cytochromes.ChemElectroChem · 2019Review
- Interfaces Between Alpha-helical Integral Membrane Proteins: Characterization, Prediction, and Docking.Computational and structural biotechnology journal · 2019Article
- Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas.Scientific reports · 2018Article
- Structural basis of Zn(II) induced metal detoxification and antibiotic resistance by histidine kinase CzcS in Pseudomonas aeruginosa.PLoS pathogens · 2017Article
- Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.Nature chemical biology · 2015Article
- New model for electron flow for sulfate reduction in Desulfovibrio alaskensis G20.Applied and environmental microbiology · 2014Article
- Catalytic mechanisms of complex II enzymes: a structural perspective.Biochimica et biophysica acta · 2013Review
- Defining a direction: electron transfer and catalysis in Escherichia coli complex II enzymes.Biochimica et biophysica acta · 2013Review
- Membrane protein native state discrimination by implicit membrane models.Journal of computational chemistry · 2013Article
- Article
- Hydrogen-bonded networks along and bifurcation of the E-pathway in quinol:fumarate reductase.Biophysical journal · 2012Article
- Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.The Journal of biological chemistry · 2010Article
- Crystal structures of all-alpha type membrane proteins.European biophysics journal : EBJ · 2010Review
- Production, characterization and determination of the real catalytic properties of the putative 'succinate dehydrogenase' from Wolinella succinogenes.Molecular microbiology · 2009Article
- A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II.The Journal of biological chemistry · 2008Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane protein complexes can support both the generation and utilisation of a transmembrane electrochemical proton potential ('proton-motive force'), either by transmembrane electron transfer coupled to protolytic reactions on opposite sides of the membrane or by transmembrane proton transfer. Here we provide the first evidence that both of these mechanisms are combined in the case of a specific respiratory membrane protein complex, the dihaem-containing quinol:fumarate reductase (QFR) of Wolinella succinogenes, so as to facilitate transmembrane electron transfer by transmembrane proton transfer. We also demonstrate the non-functionality of this novel transmembrane proton transfer pathway ('E-pathway') in a variant QFR where a key glutamate residue has been replaced. The 'E-pathway', discussed on the basis of the 1.78-Angstrom-resolution crystal structure of QFR, can be concluded to be essential also for the viability of pathogenic epsilon-proteobacteria such as Helicobacter pylori and is possibly relevant to proton transfer in other dihaem-containing membrane proteins, performing very different physiological functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.