ArticleJournal of perinatology : official journal of the California Perinatal Association2006
Safety and efficacy of early amino acids in preterm <28 weeks gestation: prospective observational comparison.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02478086 (Effects of High vs. Standard Protein Intake in the Weight Gain and Renal Function Security in Newborn Extreme Premature), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High vs. Standard Protein Intake in the Weight Gain and Renal Function Security in Newborn Extreme Premature
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Early versus late administration of amino acids in preterm infants receiving parenteral nutrition.The Cochrane database of systematic reviews · 2024Pooled it
- Trial
- Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant.Journal of perinatology : official journal of the California Perinatal Association · 2008Trial
- Case Report: A complicated case of neonatal refeeding syndrome following intrauterine growth restriction corrected by high dose thiamine supplementation.Frontiers in pediatrics · 2025Article
- Paediatric parenteral nutrition: current issues.Frontline gastroenterology · 2020Article
- Article
- Does High Protein Intake During First Week of Life Improve Growth and Neurodevelopmental Outcome at 18 months Corrected Age in Extremely Preterm Infants?Indian journal of pediatrics · 2016Article
- Impact of renal function and protein intake on blood urea nitrogen in preterm infants in the first 3 weeks of life.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Article
- Validating the weight gain of preterm infants between the reference growth curve of the fetus and the term infant.BMC pediatrics · 2013Article
- Blood urea nitrogen and serum bicarbonate in extremely low birth weight infants receiving higher protein intake in the first week after birth.Journal of perinatology : official journal of the California Perinatal Association · 2011Article
- Outcomes of early parenteral nutrition for premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2010Article
- Improved growth and decreased morbidities in <1000 g neonates after early management changes.Journal of perinatology : official journal of the California Perinatal Association · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the safety and efficacy of early amino acid (AA) administration in preterm neonates <28 weeks gestational age. STUDY
designProspective data collection for 1 year for the late AA group (AA started at 12-30 h) and for another year with practice change to early AA administration (immediately after stabilization).
resultsTime of initiation of AA differed (early group 4+/-3 h vs late group 20+/-6 h; P<0.001). There were no statistically significant differences in the incidence of clinically significant metabolic acidosis. Blood urea at 24 h was higher in the early AA group. No significant differences in growth rate or neonatal outcomes were identified. Days to regain birth weight and sepsis were lower in the early AA group.
conclusionsEarly AA administration was not associated with any clinically significant adverse effects; it was associated with reduction in the incidence of sepsis and marginally effective in reducing time to regain birth weight.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.