ArticleGenes and immunity2006
Complexity in the host response to Salmonella Typhimurium infection in AcB and BcA recombinant congenic strains.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions.Cell host & microbe · 2019Review
- Enterobacteria and host resistance to infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice.BMC genomics · 2018Article
- Mouse Chromosome 4 Is Associated with the Baseline and Allergic IgE Phenotypes.G3 (Bethesda, Md.) · 2017Article
- Complex genetics architecture contributes to Salmonella resistance in AcB60 mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages duringFrontiers in immunology · 2017Article
- Transcription factor Batf3 is important for development of CD8+ T-cell response against a phagosomal bacterium regardless of the location of antigen.Immunology and cell biology · 2016Article
- Article
- Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.Infection and immunity · 2012Article
- Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice.Physiological genomics · 2012Article
- Refinement of the genetics of the host response to Salmonella infection in MOLF/Ei: regulation of type 1 IFN and TRP3 pathways by Ity2.Genes and immunity · 2012Article
- Identification of loci controlling restriction of parasite growth in experimental Taenia crassiceps cysticercosis.PLoS neglected tropical diseases · 2011Article
- Genetic control of resistance to Trypanosoma brucei brucei infection in mice.PLoS neglected tropical diseases · 2011Article
- N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Article
- Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.The Journal of experimental medicine · 2007Article
- Susceptibility to severe Streptococcal sepsis: use of a large set of isogenic mouse lines to study genetic and environmental factors.Genes and immunity · 2007Article
- Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.Genes and immunityArticle
- The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice.Genes and immunityArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The host response to Salmonella infection is controlled by its genetic makeup. Using the mouse model of typhoid fever, several genes were found to influence the outcome of Salmonella infection, including Nramp1 (Slc11a1). In order to improve our knowledge of genetic determinants of the mouse response to acute Salmonella Typhimurium infection, we performed a systematic screening of a set of A/J and C57BL/6J recombinant congenic strains (RCS) for their resistance to infection. While we knew that the parental strains differ in their susceptibility to Salmonella because C57BL/6J mice carry a non-functional allele at Nramp1, we hypothesized that other genes would influence the response to Salmonella and segregate in the RCS. We identified several RCS that showed a non-expected phenotype given their known Nramp1 genotype proving that the response to Salmonella in A/J and C57BL/6J mice is complex. Based on these findings, we selected two RCS for generation of fully informative F2 crosses, (AcB61 x 129S6) and (AcB64 x DBA/2J). Genetic analyses performed on these crosses identified five novel Salmonella susceptibility QTL mapping to chromosomes 3 (Ity4), 2 (Ity5), 14 (Ity6), 7 (Ity7) and 15 (Ity8). These results illustrate the genetic complexity associated with the mouse response to Salmonella Typhimurium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.