ArticleJapanese journal of cancer research : Gann1990
Normal human chromosome 1 carries suppressor activity for various phenotypes of a Kirsten murine sarcoma virus-transformed NIH/3T3 cell line.
Article in Japanese journal of cancer research : Gann, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 13 citations in OpenAlex.
- Subchromosomal mapping of a putative transformation suppressor gene on human chromosome 1.Japanese journal of cancer research : Gann · 1995Article
- A gene involved in control of human cellular senescence on human chromosome 1q.Molecular and cellular biology · 1994Article
- Lessons learned from studies on tumor suppression by microcell-mediated chromosome transfer.Environmental health perspectives · 1991Review
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4 authors at 2 institutions in 1 country.
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Abstract
In order to identify chromosomes that carry putative tumor-suppressor genes for the various phenotypes of Kirsten sarcoma virus-transformed NIH/3T3 (DT) cells, we performed microcell-mediated chromosome transfer into DT cells. We first isolated mouse A9 clones, containing a single human chromosome 1, 11 or 12 tagged with pSV2-neo plasmid DNA. Then, chromosome 1, 11 or 12 was transferred from the A9 clones into DT cells by microcell fusion. The growth rate, colony-forming ability in soft agar and tumorigenicity of the DT cells were controlled by chromosome 1, but not by chromosome 11 or 12, indicating that normal human chromosome 1 carries a putative tumor-suppressor gene(s) that affects various transformed phenotypes of DT cells.
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