Trial reportAmerican journal of respiratory and critical care medicine2006
Glutathione s-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke.
Trial report in American journal of respiratory and critical care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data.International journal of epidemiology · 2010Pooled it
- Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Food & function · 2014Trial
- Diesel exhaust exposure and nasal response to attenuated influenza in normal and allergic volunteers.American journal of respiratory and critical care medicine · 2012Trial
- Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway.Clinical immunology (Orlando, Fla.) · 2009Trial
- History of pollutant adjuvants in respiratory allergy.Frontiers in allergy · 2024Review
- Indoor air pollution: An important risk factor for lung cancer among Asian women without a history of smoking.Chinese medical journal pulmonary and critical care medicine · 2023Article
- Development of a screening protocol to identify persons who are responsive to wood smoke particle-induced airway inflammation with pilot assessment of GSTM1 genotype and asthma status as response modifiers.Inhalation toxicology · 2022Article
- Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine · 2018Article
- Does aspirin-induced oxidative stress cause asthma exacerbation?Archives of medical science : AMS · 2015Article
- Nanoparticles, lung injury, and the role of oxidant stress.Annual review of physiology · 2014Review
- Allergic diseases and air pollution.Asia Pacific allergy · 2013Article
- Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy.BMC pediatrics · 2013Article
- Glutathione S-transferase P1 Ile105Val polymorphism modulates allergen-induced airway inflammation in human atopic asthmatics in vivo.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma.Journal of occupational and environmental medicine · 2012Article
- Role of GSTM1 in resistance to lung inflammation.Free radical biology & medicine · 2012Review
- Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells.Particle and fibre toxicology · 2012Article
- The effect of environmental oxidative stress on airway inflammation.Current opinion in allergy and clinical immunology · 2012Review
- Genetic and epigenetic influence on the response to environmental particulate matter.The Journal of allergy and clinical immunology · 2012Review
- Unravelling gene-by-environment effects in asthma and allergy: the glutathione pathway as an early success story.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Article
- Oxidative stress in asthma.The World Allergy Organization journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
rationaleSecondhand tobacco smoke (SHS) and traffic-related air pollutants are associated with asthma and allergy. Diesel exhaust particles (DEPs) and SHS can interact with allergens in exacerbating allergic airway diseases through generation of reactive oxygen species. Glutathione S-transferases (GSTs) metabolize reactive oxygen species and detoxify electrophilic xenobiotics present in SHS and DEPs.
objectivesWe tested the hypotheses that functional GSTM1-null genotype and GSTP1 codon 105 variants (Ile105 and Val105) are determinants of allergic responses to SHS, and that responses to SHS and DEPs are correlated. METHODS AND MEASUREMENTS: In a randomized, placebo-controlled crossover trial, 19 ragweed allergen-sensitive subjects who had previously participated in a DEP trial were challenged intranasally with allergen after having been exposed to either clean air or SHS at separate visits. Nasal allergen-specific IgE, histamine, IL-4, and IFN-gamma levels were measured before and after allergen challenge. MAIN
resultsIndividuals with GSTM1-null or GSTP1 Ile105 genotypes showed larger nasal responses to allergens with SHS compared with clean air. GSTM1-null subjects had a larger increase in IgE than GSTM1-present subjects (median, 173.3 vs. 46.7 U/ml; p = 0.03), and the Ile105 GSTP1 genotype subjects had increased histamine (median, 10.2 vs. 4.6 nM; p = 0.01) after SHS plus allergen challenge. Responses to SHS and DEPs were correlated. Enhancement of IgE and histamine was greatest in the subjects with both the GSTM1-null and GSTP1 Ile/Ile genotypes.
conclusionsGSTM1 and GSTP1 are important cytoprotective factors that reduce SHS and DEP exacerbation of allergic responses.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.