Trial reportBMJ (Clinical research ed.)2006
Effect of beta radiation on success of glaucoma drainage surgery in South Africa: randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Overview of cicatricial modulators in glaucoma fistulizing surgery.International ophthalmology · 2020Pooled it
- Beta radiation for glaucoma surgery.The Cochrane database of systematic reviews · 2012Pooled it
- Trial
- Glaucoma Management Therapies and Clinical Outcomes in an African Population: A Review of Prospective Studies.Journal of clinical medicine · 2026Review
- Yttrium-90 (American journal of ophthalmology case reports · 2024Article
- The cost-effectiveness of medication, laser trabeculoplasty, and trabeculectomy for treatment of open-angle glaucoma in South Korea.Medicine · 2019Article
- Management Of Glaucoma In Developing Countries: Challenges And Opportunities For Improvement.ClinicoEconomics and outcomes research : CEOR · 2019Review
- Safety and effectiveness of primary transscleral diode laser cyclophotoablation for glaucoma in Nigeria.Clinical & experimental ophthalmology · 2018Article
- Trabeculectomy with ologen in secondary glaucomas following failed trabeculectomy with MMC: comparative study.Eye (London, England) · 2016Article
- Glaucoma, "the silent thief of sight": patients' perspectives and health seeking behaviour in Bauchi, northern Nigeria.BMC ophthalmology · 2016Article
- Current and Future Techniques in Wound Healing Modulation after Glaucoma Filtering Surgeries.The open ophthalmology journal · 2016Article
- Different strategies and cost-effectiveness in the treatment of primary open angle glaucoma.ClinicoEconomics and outcomes research : CEOR · 2014Review
- Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma.International journal of ophthalmology · 2013Article
- A new manner of reporting pressure results after glaucoma surgery.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- A comparative study of mitomycin C and 5-Fluorouracil trabeculectomy in west Africa.Middle East African journal of ophthalmology · 2012Article
- Glaucoma in the developing world.BMJ (Clinical research ed.) · 2006Article
- Yttrium-90 Episcleral Plaque Brachytherapy for Choroidal Melanoma.Journal of vitreoretinal diseasesArticle
- High-Dose-Rate Yttrium-90 (Ophthalmology scienceArticle
- LONG TERM OUTCOMES OF AUGMENTED TRABECULECTOMY WITH 5-FLUOROURACIL IN NIGERIA.Journal of the West African College of SurgeonsArticle
- Glaucomagenesis following ionizing radiation exposure.Mutation research. Reviews in mutation researchReview
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveTo evaluate whether beta radiation may offer a practical method of improving surgical success for glaucoma drainage surgery in South Africa.
designDouble blind, randomised controlled trial.
settingThree public hospitals in South Africa.
participants450 black Africans with primary glaucoma.
interventionsTrabeculectomy with 1000 cGy beta radiation or standard trabeculectomy without beta radiation (placebo).
main outcome measuresPrimary outcome measure was surgical failure within 12 months (intraocular pressure > 21 mm Hg while receiving no treatment for ocular hypotension). Secondary outcomes were visual acuity, surgical reintervention for cataract, and intraoperative and postoperative complications.
results320 people were recruited. beta radiation was given to 164; 20 (6%) were not seen again after surgery. One year after surgery the estimated risk of surgical failure was 30% (95% confidence interval 22% to 38%) in the placebo arm compared with 5% (2% to 10%) in the radiation arm. The radiation group experienced a higher incidence of operable cataract (18 participants) than the placebo group (five participants; P = 0.01). At two years the estimated risks with placebo and beta radiation were, respectively, 2.8% (0.9% to 8.3%) and 16.7% (10.0% to 27.3%).
conclusionbeta radiation substantially reduced the risk of surgical failure after glaucoma surgery. Some evidence was, however, found of an increased risk for cataract surgery (a known complication of trabeculectomy) in the beta radiation arm during the two years after surgery.
trial registrationISRCTN62430622 [controlled-trials.com].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.