ArticleVirology2007
Structures required for poly(A) tail-independent translation overlap with, but are distinct from, cap-independent translation and RNA replication signals at the 3' end of Tobacco necrosis virus RNA.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Mapping the RNA structural landscape of viral genomes.Methods (San Diego, Calif.) · 2020Article
- Article
- Design and Development of Modified mRNA Encoding Core Antigen of Hepatitis C Virus: a Possible Application in Vaccine ProductionIranian biomedical journal · 2019Article
- Atypical RNA Elements Modulate Translational Readthrough in Tobacco Necrosis Virus D.Journal of virology · 2017Article
- Cis- and trans-regulation of luteovirus gene expression by the 3' end of the viral genome.Virus research · 2015Review
- Identification of an internal RNA element essential for replication and translational enhancement of tobacco necrosis virus A(C).PloS one · 2013Article
- Poly(A)-binding protein facilitates translation of an uncapped/nonpolyadenylated viral RNA by binding to the 3' untranslated region.Journal of virology · 2012Article
- Untranslated regions of diverse plant viral RNAs vary greatly in translation enhancement efficiency.BMC biotechnology · 2012Article
- Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation.Journal of virology · 2009Article
- The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits.RNA (New York, N.Y.) · 2008Article
- Rose spring dwarf-associated virus has RNA structural and gene-expression features like those of Barley yellow dwarf virus.Virology · 2008Article
- The amazing diversity of cap-independent translation elements in the 3'-untranslated regions of plant viral RNAs.Biochemical Society transactions · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tobacco necrosis necrovirus (TNV) RNA lacks both a 5' cap and a poly(A) tail but is translated efficiently, owing in part to a Barley yellow dwarf virus (BYDV)-like cap-independent translation element (BTE) in its 3' untranslated region (UTR). Here, we identify sequence downstream of the BTE that is necessary for poly(A) tail-independent translation in vivo by using RNA encoding a luciferase reporter gene flanked by viral UTRs. Deletions and point mutations caused loss of translation that was restored by adding a poly(A) tail, and not by adding a 5' cap. The two 3'-proximal stem-loops in the viral genome contribute to poly(A) tail-independent translation, as well as RNA replication. For all necroviruses, we predict a conserved 3' UTR secondary structure that includes the BTE at one end of a long helical axis and the stem-loops required for poly(A) tail-independent translation and RNA replication at the other end. This work shows that a viral genome can harbor distinct cap- and poly(A) tail-mimic sequences in the 3' UTR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.