ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2007
Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- The structure and function of taste G protein-coupled receptors and their implications in diseases.International journal of oral science · 2026Review
- Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration.European journal of pharmacology · 2024Article
- Bitter taste receptors in the reproductive system: Function and therapeutic implications.Journal of cellular physiology · 2024Review
- Bitter Taste Receptors and Endocrine Disruptors: Cellular and Molecular Insights from an In Vitro Model of Human Granulosa Cells.International journal of molecular sciences · 2022Article
- Taste receptors affect male reproduction by influencing steroid synthesis.Frontiers in cell and developmental biology · 2022Review
- Review
- Expression of Taste Receptor 2 Subtypes in Human Testis and Sperm.Journal of clinical medicine · 2020Article
- Taste Receptors: New Players in Sperm Biology.International journal of molecular sciences · 2019Review
- System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools.Molecular medicine reports · 2018Article
- Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract.PloS one · 2014Article
- Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Functional characterization of bitter-taste receptors expressed in mammalian testis.Molecular human reproduction · 2013Article
- Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice.Molecular human reproduction · 2012Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although chemotaxis has been proposed to guide sperm to egg throughout the animal kingdom, sperm attractants released from mammalian eggs have not been identified. Since the G protein subunit alpha-gustducin is accepted as a marker of chemosensitive cells, attempts were made to explore whether alpha-gustducin is also expressed in spermatozoa of mammals. Immunohistochemical approaches using an anti-alpha-gustducin-specific antibody revealed the most intense immunoreactivity in differentiating spermatids. Further evidence for the alpha-gustducin expression was obtained analyzing testicular and sperm-derived tissue preparations in western blot analyses. To elucidate whether alpha-gustducin is retained in mature spermatozoa, epididymal mouse and rat sperm were subjected to immunocytochemistry as well as immunogold electron microscopy. A specific staining was obtained within the circumference of the midpiece-localized mitochondria, on the axoneme and the outer dense fibers surrounding the microtubules of this region, whereas no labeling was detectable in the end piece regions. The analysis of ejaculated bovine and human sperm revealed a comparable segmental distribution pattern for alpha-gustducin. Although a possible function for alpha-gustducin has yet to be determined, the axonemal-associated localization within the midpiece and principal piece of different mammalian spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility.
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