ArticleEuropean journal of nuclear medicine and molecular imaging2007
Bone involvement in patients with lymphoma: the role of FDG-PET/CT.
Article in European journal of nuclear medicine and molecular imaging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 122 citations in OpenAlex.
- Early treatment response evaluation in patients with diffuse large B-cell lymphoma--a pilot study comparing volumetric MRI and PET/CT.Molecular imaging and biology · 2011Trial
- The Role of [Cancers · 2025Article
- Diffuse large B-cell lymphoma involving osseous sites: utility of response assessment by PET/CT and good longterm outcomes.Haematologica · 2024Article
- Phantom-based acquisition time and image reconstruction parameter optimisation for oncologic FDG PET/CT examinations using a digital system.BMC cancer · 2022Article
- Article
- Impact of High-Dose Methotrexate on the Outcome of Patients with Diffuse Large B-Cell Lymphoma and Skeletal Involvement.Cancers · 2021Article
- Article
- Differential diagnostic value ofJournal of bone oncology · 2020Article
- Case of polyostotic primary bone lymphoma successfully treated with immunochemotherapy and consolidation radiotherapy.BMJ case reports · 2017Article
- The Clinical Utility of FDG PET-CT in Evaluation of Bone Marrow Involvement by Lymphoma.Cancer research and treatment · 2015Article
- Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- Characterizing bone marrow involvement in Hodgkin's lymphoma by FDG-PET/CT.European journal of nuclear medicine and molecular imaging · 2014Article
- Utility of fluorodeoxyglucose positron emission tomography/computed tomography in patients with fever of unknown origin diagnosed as lymphoma.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2014Article
- State-of-the-Art Research on "Lymphomas: Role of Molecular Imaging for Staging, Prognostic Evaluation, and Treatment Response".Frontiers in oncology · 2013Review
- Usefulness of (18)F-FDG PET/CT for the Evaluation of Bone Marrow Involvement in Patients with High-Grade Non-Hodgkin's Lymphoma.Nuclear medicine and molecular imaging · 2012Article
- The diagnostic value of FDG-PET cannot be judged by iliac bone marrow biopsy.The British journal of radiology · 2012Article
- Clinical utility of ¹⁸F FDG-PET/CT in the detection of bone marrow disease in Hodgkin's lymphoma.The British journal of radiology · 2012Article
- Biopsy versus FDG PET/CT in the initial evaluation of bone marrow involvement in pediatric lymphoma patients.European journal of nuclear medicine and molecular imaging · 2011Article
- Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma: A Step towards Personalized Care.International journal of molecular imaging · 2011Article
- Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients.Cancer · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the diagnostic impact and clinical significance of FDG-avid bone lesions detected by FDG-PET/CT in patients with lymphoma.
methodsThe study population comprised 50 consecutive patients (mean age 41.7+/-15.5 years; 27 female, 23 male; 41 staging, 9 restaging) with Hodgkin's disease (n=22) or aggressive non-Hodgkin's lymphoma (n=28) in whom FDG-avid bone lesions were detected by FDG-PET/CT. All patients had either direct biopsy of the FDG-avid bone lesion (n=18), standard bone marrow biopsy at the iliac crest (BMB; n=43) or both procedures (n=11). In 15 patients, additional MRI of the bone lesions was performed. All patients underwent FDG-PET/CT after the end of treatment. All CT images of FDG-PET/CT scans were analysed independently regarding morphological osseous changes and compared with FDG-PET results.
resultsIn the 50 patients, 193 FDG-avid lesions were found by PET/CT. The mean standardised uptake value was 6.26 (+/-3.22). All direct bone biopsies (n=18) of the FDG-avid lesions proved the presence of lymphomatous infiltration. BMB (n=43) was positive in 12 patients (27.9%). In CT, 32 of 193 (16.6%) lesions were detected without the PET information. No additional morphological bone infiltration was detected on CT compared with FDG-PET. All morphological bone alterations on CT scans persisted after the end of therapy. Additional PET/CT information regarding uni- or multifocal bone involvement resulted in lymphoma upstaging in 21 (42%) patients compared with the combined information provided by CT and BMB.
conclusionIn patients with FDG-avid bone lesions, FDG-PET is superior to CT alone or in combination with unilateral BMB in detecting bone marrow involvement, leading to upstaging in a relevant proportion of patients.
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