ArticleInternational journal of colorectal disease2007
Different matrix micro-environments in colon cancer and diverticular disease.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Evaluation of molecular and genetic predisposing parameters at diverticular disease of the colon.International journal of colorectal disease · 2021Review
- Hernia and Cancer: The Points Where the Roads Intersect.Frontiers in surgery · 2019Review
- Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing.Human molecular genetics · 2017Article
- Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum.World journal of gastroenterology · 2016Review
- Different Types of Periampullary Duodenal Diverticula Are Associated with Occurrence and Recurrence of Bile Duct Stones: A Case-Control Study from a Chinese Center.Gastroenterology research and practice · 2016Article
- The Nyhus-Wantz lectureship: etiology, herniosis, diverticulosis coli, and cancer.Hernia : the journal of hernias and abdominal wall surgery · 2011Review
- Systemic hernial disease protects against cancer: an hypothesis.Hernia : the journal of hernias and abdominal wall surgery · 2010Article
- Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures.Langenbeck's archives of surgery · 2010Article
- Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies.International journal of colorectal disease · 2008Article
- Paradigm shift: the Copernican revolution in diverticular disease.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe extracellular matrix and the interactive signalling between its components are thought to play a pivotal role for tumour development and metastasis formation. An altered matrix composition as potential underlying pathology for the development of colorectal cancer was hypothesized.
methodsIn a retrospective study of patients with colon cancer, the extracellular matrix in tumour-free bowel specimen was investigated in comparison with non-infected bowel specimen from patients operated on for colonic diverticulosis. The following matrix parameters with known associations to tumour formation, cell proliferation, invasion and metastasis were analysed by immunohistochemistry and quantified by a scoring system: VEGF, TGF-beta, ESDN, CD117, c-erb-2, cyclin D1, p53, p27, COX-2, YB-1, collagen I/III, MMP-13, PAI and uPAR. Expression profiles and correlations were calculated.
resultsThe comparison of the two groups revealed a significantly decreased immunostaining for CD117 and TGF-beta in the cancer group (8.5+/-2.6 vs 10.3+/-2,1 and 4.9+/-1.5 vs 8.1+/-3, respectively), whereas PAI scores were significantly higher than in patients with diverticular disease (8.1+/-1.6 vs 6.2+/-0.9). Overall correlation patterns of matrix parameters indicated pronounced differences between tumour-free tissue in cancer patients compared with patients with diverticular disease.
conclusionsOur results indicate distinct differences in the colonic tissue architecture between cancer patients and patients with diverticulitis that support the notion of an altered matrix composition predisposing to the development of colon cancer.
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