ArticleInternational journal of colorectal disease2007
Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis.Cancer medicine · 2019Pooled it
- The Effect of Right Colon Retroflexion on Adenoma Detection: A Systematic Review and Meta-analysis.Journal of clinical gastroenterology · 2017Pooled it
- Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Pooled it
- Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison study.The American journal of gastroenterology · 2015Trial
- Oncologic outcomes and trends in each colon cancer location and stages over the last two decades: insights from the SEER registry.Techniques in coloproctology · 2024Article
- Clinicopathological features and prognosis analysis of proximal colonic mucinous adenocarcinoma.Scientific reports · 2024Article
- The association between educational status and colorectal neoplasia: results from a screening cohort.International journal of colorectal disease · 2023Article
- Validation of post-colonoscopy colorectal cancer (PCCRC) cases reported at national level following local root cause analysis: REFLECT study.Frontline gastroenterology · 2022Article
- Right sided colorectal cancer increases with age and screening should be tailored to reflect this: a national cancer database study.Techniques in coloproctology · 2021Article
- Primary tumor location affects recurrence-free survival for patients with colorectal liver metastases after hepatectomy: a propensity score matching analysis.World journal of surgical oncology · 2020Article
- The Impact of Primary Tumor Sidedness on the Effect of Regorafenib in Refractory Metastatic Colorectal Cancer.Journal of Cancer · 2019Article
- ADR evaluation of screening colonoscopies during 2016 - 2017 in a private health clinic in Peru.Endoscopy international open · 2018Article
- Pathologic factors are more important than tumor location in long-term survival in colon cancer.International journal of colorectal disease · 2018Article
- Expression of Hippo pathway genes and their clinical significance in colon adenocarcinoma.Oncology letters · 2018Article
- Article
- Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression.Journal of cancer metastasis and treatment · 2018Article
- Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer?Annals of coloproctology · 2017Article
- Myeloperoxidase expression in human colonic mucosa is related to systemic oxidative balance in healthy subjects.Redox report : communications in free radical research · 2017Article
- Left-sided primary tumor is a favorable prognostic factor for metastatic colorectal cancer patients receiving surgery.Oncotarget · 2017Article
- Differential expression of M3 muscarinic receptors in progressive colon neoplasia and metastasis.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsColorectal cancer (CRC) ranks as the fourth most frequently diagnosed cancer worldwide. CRCs that arise proximally or distally to the splenic flexure show differences in epidemiologic incidence, morphology, and molecular alterations, suggesting the existence of two categories of CRC based on the site of origin. The aim of the present work is to investigate the histological and molecular differences between CRCs located proximally and distally to the splenic flexure, and their potential involvement in tumor prognosis and therapeutic strategies.
methodsWe evaluated 120 patients affected by sporadic CRC for clinicopathologic features, microsatellite instability (MSI), loss of heterozygosity (LOH) of chromosomes 18q, 8p, and 4p; they were also investigated for hMlh1, hMsh2, Fhit, p27, and Cox-2 immunostaining.
resultsThe mucinous histotype was more frequent in the proximal than in the distal CRCs (p<0.004). The frequency of MSI phenotype was higher in proximal than in distal tumors (p<0.001); moreover, reduced or absent hMlh1, Fhit, p27 immunohistochemical expressions were more frequent in proximal than in distal tumors (p<0.001 and 0.01 for p27). In contrast, the frequency of LOH in 18q was higher in distal than in proximal tumors (p=0.002). No significant differences were observed between proximal and distal tumors in the frequency of LOH in 8p and altered expression of hMsh2 and p53 protein.
conclusionThese different features may reflect different genetic pathways of carcinogenesis and support the hypothesis of a different mechanism of cancer development between the proximal and the distal colon, with potential implications in the therapeutic approach.
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