ArticleMolecular biology of the cell2006
Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
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- Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance.bioRxiv : the preprint server for biology · 2023Article
- CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells.Metabolic engineering · 2023Article
- Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage.Nature communications · 2022Article
- IFT20 Mediates the Transport of Cell Migration Regulators From the Trans-Golgi Network to the Plasma Membrane in Breast Cancer Cells.Frontiers in cell and developmental biology · 2021Article
- A non-canonical rhodopsin-mediated insulin receptor signaling pathway in retinal photoreceptor neurons.Cell biology international · 2020Article
- Golgi pH, Ion and Redox Homeostasis: How Much Do They Really Matter?Frontiers in cell and developmental biology · 2019Article
- A Kinetic View of Membrane Traffic Pathways Can Transcend the Classical View of Golgi Compartments.Frontiers in cell and developmental biology · 2019Review
- SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.BMC bioinformatics · 2017Review
- Article
- Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells.BMC biotechnology · 2015Article
- The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis.American journal of physiology. Cell physiology · 2015Article
- Chronic alcohol exposure affects the cell components involved in membrane traffic in neuronal dendrites.Neurotoxicity research · 2015Article
- Golgi phosphoprotein 3 triggers signal-mediated incorporation of glycosyltransferases into coatomer-coated (COPI) vesicles.The Journal of biological chemistry · 2014Article
- An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation.The Journal of biological chemistry · 2014Article
- TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport.Journal of cell science · 2014Article
- Article
- A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIA.Glycobiology · 2013Article
- Non-muscle myosin IIA transports a Golgi glycosyltransferase to the endoplasmic reticulum by binding to its cytoplasmic tail.The international journal of biochemistry & cell biology · 2012Article
- Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.Molecular pharmacology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Golgi apparatus (GA) is the organelle where complex glycan formation takes place. In addition, it is a major sorting site for proteins destined for various subcellular compartments or for secretion. Here we investigate beta1,4-galactosyltransferase 1 (galT) and alpha2,6-sialyltransferase 1 (siaT), two trans-Golgi glycosyltransferases, with respect to their different pathways in monensin-treated cells. Upon addition of monensin galT dissociates from siaT and the GA and accumulates in swollen vesicles derived from the trans-Golgi network (TGN), as shown by colocalization with TGN46, a specific TGN marker. We analyzed various chimeric constructs of galT and siaT by confocal fluorescence microscopy and time-lapse videomicroscopy as well as Optiprep density gradient fractionation. We show that the first 13 amino acids of the cytoplasmic tail of galT are necessary for its localization to swollen vesicles induced by monensin. We also show that the monensin sensitivity resulting from the cytoplasmic tail can be conferred to siaT, which leads to the rapid accumulation of the galT-siaT chimera in swollen vesicles upon monensin treatment. On the basis of these data, we suggest that cycling between the trans-Golgi cisterna and the trans-Golgi network of galT is signal mediated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.