ArticleApplied and environmental microbiology2006
Pleiotropic role of quorum-sensing autoinducer 2 in Photorhabdus luminescens.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Dissecting the invasion of Galleria mellonella by Yersinia enterocolitica reveals metabolic adaptations and a role of a phage lysis cassette in insect killing.PLoS pathogens · 2022Article
- Pyrones Identified as LuxR Signal Molecules inACS omega · 2021Article
- Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival inCells · 2021Article
- Toxin production spontaneously becomes regulated by local cell density in evolving bacterial populations.PLoS computational biology · 2019Article
- Unraveling the role of quorum sensing-dependent metabolic homeostasis of the activated methyl cycle in a cooperative population of Burkholderia glumae.Scientific reports · 2019Article
- LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis inPeerJ · 2017Article
- DNA Adenine Methyltransferase (Dam) Overexpression ImpairsFrontiers in microbiology · 2017Article
- The Vibrio cholerae Cpx envelope stress response senses and mediates adaptation to low iron.Journal of bacteriology · 2015Article
- From Insect to Man: Photorhabdus Sheds Light on the Emergence of Human Pathogenicity.PloS one · 2015Article
- Biofilm formation, host-cell adherence, and virulence genes regulation of Streptococcus suis in response to autoinducer-2 signaling.Current microbiology · 2014Article
- Analysis of autoinducer-2 quorum sensing in Yersinia pestis.Infection and immunity · 2013Article
- Detection of AI-2 receptors in genomes of Enterobacteriaceae suggests a role of type-2 quorum sensing in closed ecosystems.Sensors (Basel, Switzerland) · 2012Review
- Transcriptional analysis of a Photorhabdus sp. variant reveals transcriptional control of phenotypic variation and multifactorial pathogenicity in insects.Applied and environmental microbiology · 2011Article
- Nooks and crannies in type VI secretion regulation.Journal of bacteriology · 2010Review
- Identification of functional LsrB-like autoinducer-2 receptors.Journal of bacteriology · 2009Article
- Article
- Symbiotic conversations are revealed under genetic interrogation.Nature reviews. Microbiology · 2008Review
- Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria.BMC microbiology · 2008Article
- Photorhabdus luminescens genes induced upon insect infection.BMC genomics · 2008Article
- Cinnamic acid, an autoinducer of its own biosynthesis, is processed via Hca enzymes in Photorhabdus luminescens.Applied and environmental microbiology · 2008Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial virulence is an integrative process that may involve quorum sensing. In this work, we compared by global expression profiling the wild-type entomopathogenic Photorhabdus luminescens subsp. laumondii TT01 to a luxS-deficient mutant unable to synthesize the type 2 quorum-sensing inducer AI-2. AI-2 was shown to regulate more than 300 targets involved in most compartments and metabolic pathways of the cell. AI-2 is located high in the hierarchy, as it controls the expression of several transcriptional regulators. The regulatory effect of AI-2 appeared to be dose dependent. The luxS-deficient strain exhibited decreased biofilm formation and increased type IV/V pilus-dependent twitching motility. AI-2 activated its own synthesis and transport. It also modulated bioluminescence by regulating the synthesis of spermidine. AI-2 was further shown to increase oxidative stress resistance, which is necessary to overcome part of the innate immune response of the host insect involving reactive oxygen species. Finally, we showed that the luxS-deficient strain had attenuated virulence against the lepidopteran Spodoptera littoralis. We concluded that AI-2 is involved mainly in early steps of insect invasion in P. luminescens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.