ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 116 citations in OpenAlex.
- Multi-omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells.Experimental physiology · 2026Article
- Persistence of vestibular function in the absence of glutamatergic transmission from hair cells.Scientific reports · 2026Article
- Transient capacitance changes recorded from vestibular type I hair cells are produced by GThe Journal of physiology · 2025Article
- A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla.The Journal of comparative neurology · 2025Article
- Close Packing of Cells in Vestibular Epithelia Supports Local Electrical Potentials that Reduce Latency of Action Potential Generation.bioRxiv : the preprint server for biology · 2025Article
- Pimozide Inhibits Type II but Not Type I Hair Cells in Chicken Embryo and Adult Mouse Vestibular Organs.Biomedicines · 2024Article
- The potassium channel subunit KeLife · 2024Article
- The potassium channel subunit KbioRxiv : the preprint server for biology · 2024Article
- Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci.International journal of molecular sciences · 2024Article
- Vestibular hair cells are more prone to damage by excessive acceleration insult in the mouse with KCNQ4 dysfunction.Scientific reports · 2024Article
- Electrophysiological properties of vestibular hair cells isolated from human crista.Frontiers in neurology · 2024Article
- Expression of hyperpolarization-activated current (Journal of neurophysiology · 2023Article
- Pimozide Increases a Delayed Rectifier KBiomedicines · 2023Article
- Nonquantal transmission at the vestibular hair cell-calyx synapse: KProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics.Cell reports · 2021Article
- Article
- Cholinergic Modulation of Membrane Properties of Calyx Terminals in the Vestibular Periphery.Neuroscience · 2021Article
- Current Response in CaFrontiers in neuroscience · 2021Article
- Similarities in the Biophysical Properties of Spiral-Ganglion and Vestibular-Ganglion Neurons in Neonatal Rats.Frontiers in neuroscience · 2021Article
- Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Type I vestibular hair cells have large K+ currents that, like neuronal M currents, activate negative to resting potential and are modulatable. In rodents, these currents are acquired postnatally. In perforated-patch recordings from rat utricular hair cells, immature hair cells [younger than postnatal day 7 (P7)] had a steady-state K+ conductance (g(-30)) with a half-activation voltage (V1/2) of -30 mV. The size and activation range did not change in maturing type II cells, but, by P16, type I cells had added a K conductance that was on average fourfold larger and activated much more negatively. This conductance may comprise two components: g(-60) (V1/2 of -60 mV) and g(-80) (V1/2 of -80 mV). g(-80) washed out during ruptured patch recordings and was blocked by a protein kinase inhibitor. M currents can include contributions from KCNQ and ether-a-go-go-related (erg) channels. KCNQ and erg channel blockers both affected the K+ currents of type I cells, with KCNQ blockers being more potent at younger than P7 and erg blockers more potent at older than P16. Single-cell reverse transcription-PCR and immunocytochemistry showed expression of KCNQ and erg subunits. We propose that KCNQ channels contribute to g(-30) and g(-60) and erg subunits contribute to g(-80). Type I hair cells are contacted by calyceal afferent endings. Recordings from dissociated calyces and afferent endings revealed large K+ conductances, including a KCNQ conductance. Calyx endings were strongly labeled by KCNQ4 and erg1 antisera. Thus, both hair cells and calyx endings have large M-like K+ conductances with the potential to control the gain of transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.