Evidence map›Paper›PMID 17021120›Full record

ArticleJournal of clinical microbiology2006

Evaluation of molecular-Beacon, TaqMan, and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide polymorphisms in mixed Mycobacterium tuberculosis DNA extracts.

Hasan Yesilkaya, Francesca Meacci, Stefan Niemann, Doris Hillemann, Sabine Rüsch-Gerdes, LONG DRUG Study Group, Michael R Barer, Peter W Andrew, Marco R Oggioni

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. Design of FRET Probes for SNP RS1006737, Related to Mood Disorder.Clinical practice and epidemiology in mental health : CP & EMH · 2018
    Article
  4. Article
  5. Article
  6. ERAIZDA: a model for holistic annotation of animal infectious and zoonotic diseases.Database : the journal of biological databases and curation · 2015
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Surpassing specificity limits of nucleic acid probes via cooperativity.The Journal of molecular diagnostics : JMD · 2010
    Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hasan YesilkayaDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom.
Francesca Meacci
Stefan Niemann
Doris Hillemann
Sabine Rüsch-Gerdes
LONG DRUG Study Group
Michael R Barer
Peter W Andrew
Marco R Oggioni

Funding

Medical Research Council G0300403
6 · The paper itself

Abstract

The ability of fluorescence resonance energy transfer, molecular-beacon, and TaqMan probes to detect single nucleotide polymorphism (SNP) in the presence of a wild-type allele was evaluated using drug resistance-conferring SNPs in mixed Mycobacterium tuberculosis DNA. It was found that both the absolute quantity and the ratio of alleles determine the detection sensitivity of the probe systems.

Indexed as

Nucleic Acid ProbesAntitubercular AgentsDNA, BacterialDrug Resistance, BacterialFluorescence Resonance Energy TransferMycobacterium tuberculosisPolymerase Chain ReactionPolymorphism, Single NucleotideAntitubercular AgentsDNA, BacterialNucleic Acid Probes

Identifiers

PMID17021120
PMCPMC1594805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.