ArticleJournal of clinical microbiology2006
Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- The microbiology of impetigo in indigenous children: associations between Streptococcus pyogenes, Staphylococcus aureus, scabies, and nasal carriage.BMC infectious diseases · 2014Trial
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- Control of a hospital outbreak with methicillin-resistant Staphylococcus argenteus in The Netherlands, June-September 2023.Antimicrobial resistance and infection control · 2026Article
- Emergence and genomic adaptation of the globally disseminated ST2250 lineage within theAntimicrobial agents and chemotherapy · 2026Article
- Prosthetic Joint Infection Caused byInfection and drug resistance · 2026Article
- TheJournal of clinical microbiology · 2025Review
- Unmasking Methicillin-resistantFrontiers in microbiology · 2025Article
- Prevalence and genomic insights into type III-A CRISPR-Cas system acquisition in globalFrontiers in cellular and infection microbiology · 2025Article
- Isolation and Genomic Analysis of a Case ofMicroorganisms · 2024Article
- Characterisation of PVL-PositiveAntibiotics (Basel, Switzerland) · 2024Article
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- A comprehensive technology strategy for microbial identification and contamination investigation in the sterile drug manufacturing facility-a case study.Frontiers in microbiology · 2024Article
- Prevalence and Characteristics of InvasiveMicroorganisms · 2023Article
- Clonal Complexes Distribution ofAntibiotics (Basel, Switzerland) · 2023Article
- Investigating the Antibacterial Properties of Prospective Scabicides.Biomedicines · 2022Article
- Genetic Characteristics of Methicillin-Resistant Staphylococcus argenteus Isolates Collected in the Dutch National MRSA Surveillance from 2008 to 2021.Microbiology spectrum · 2022Article
- Review
- First Report of a Methicillin-Resistant, High-Level Mupirocin-ResistantFrontiers in cellular and infection microbiology · 2022Article
- An amplification-free ultra-sensitive electrochemical CRISPR/Cas biosensor for drug-resistant bacteria detection.Chemical science · 2021Article
- Distribution of Virulence Factors and Resistance Determinants in Three Genotypes ofPathogens (Basel, Switzerland) · 2021Article
2 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a major public health problem in Australia, as in many other parts of the world. High rates of CA-MRSA skin and soft tissue infection have been reported from Aboriginal communities. We used a single-nucleotide polymorphism (SNP) genotyping typing system based on the multilocus sequence type (MLST) database to investigate the epidemiology of CA-MRSA and methicillin-sensitive S. aureus (MSSA) over a 12-month period in three remote Aboriginal communities of Northern Australia. This was supplemented by real-time PCR for Panton-Valentine leukocidin (PVL) genes, staphylococcal cassette chromosome mec (SCCmec) typing, and antimicrobial susceptibility testing. S. aureus was recovered from pyoderma lesions on 221 occasions and throat swabs on 44 occasions. The median monthly recovery rate of S. aureus from skin sores was 58% (interquartile range, 62 to 78%), and there was no seasonal variation. Twenty-three percent of isolates were CA-MRSA; the proportion was similar across the communities and did not vary over the study period. Erythromycin resistance was found in 47% of CA-MRSA and 21% of MSSA. SNP-based typing identified 14 different clonal complexes (cc); however, cc75 was predominant, accounting for 71% of CA-MRSA isolates. These were confirmed as ST75-like by using an additional SNP and MLST of selected isolates. All but one of the cc75 isolates had SSCmec type IV (one had type V), and all were PVL negative. Monthly tracking of SNP-based cc types showed a highly dynamic process. ST75-MRSA-IV appears to be unique to the region and probably evolved de novo in remote Aboriginal communities.
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