ArticleJournal of clinical microbiology2006
Candida albicans strain maintenance, replacement, and microvariation demonstrated by multilocus sequence typing.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- The Mcu1 mitochondrial protein coordinates TCA cycle enzymes to modulate phenotypic switching and commensalism inVirulence · 2026Article
- Antifungal Susceptibility and Multilocus Sequence Typing of Pichia kudriavzevii (Candida krusei) from a Tertiary Hospital in Shanghai.Mycopathologia · 2026Article
- Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.Gut microbes · 2025Review
- Chimeric PRR T-cell-engager targeting cell surface β-1,3-glucan for invasive candidiasis.PLoS pathogens · 2025Article
- Candida krusei (Pichia kudriavzevii) multilocus sequence typing and antifungal susceptibility profile in Cameroon.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Candida albicans in the oral cavities of pets: biofilm formation, putative virulence, antifungal resistance profiles and classification of the isolates.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Potential Environmental Reservoirs ofJournal of fungi (Basel, Switzerland) · 2024Review
- A gain-of-function mutation in zinc cluster transcription factor Rob1 drives Candida albicans adaptive growth in the cystic fibrosis lung environment.PLoS pathogens · 2024Article
- Farnesol remodels the peritoneal cavity immune environment influencingInfection and immunity · 2023Article
- Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization.Science immunology · 2023Article
- Anaerobic conditions are a major influence on Candida albicans chlamydospore formation.Folia microbiologica · 2023Article
- A New Approach for the Treatment of Recurrent Vulvovaginal Candidiasis with a Combination of Pea Protein, Grape Seed Extract, and Lactic Acid Assessed In Vivo.Journal of fungi (Basel, Switzerland) · 2022Article
- Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria.Cell host & microbe · 2022Article
- Article
- Identification of Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2021Article
- Organ-specific mechanisms linking innate and adaptive antifungal immunity.Seminars in cell & developmental biology · 2019Review
- The Hidden Cost of Modern Medical Interventions: How Medical Advances Have Shaped the Prevalence of Human Fungal Disease.Pathogens (Basel, Switzerland) · 2019Review
- Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.Cell host & microbe · 2019Article
- Within-Host Genomic Diversity of Candida albicans in Healthy Carriers.Scientific reports · 2019Article
- Fungal Symbionts Produce Prostaglandin EFrontiers in cellular and infection microbiology · 2019Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
We typed 165 Candida albicans isolates from 44 different sources by multilocus sequence typing (MLST) and ABC typing of rRNA genes and determined their homozygosity or heterozygosity at the mating-type-like locus (MTL). The isolates represented pairs or larger sets from individual sources, which allowed the determination of strain diversity within patients. A comparison of replicate sequence data determined a reproducibility threshold for regarding isolates as MLST indistinguishable. For 36 isolate sets, MLST and ABC typing showed indistinguishable or highly related strain types among isolates from different sites or from the same site at different times from each patient. This observation included 11 sets with at least one isolate from a blood culture and a nonsterile site from the same patient. For one patient, strain replacement was evidenced in the form of two sets of isolates from different hospital admissions where the strain types within each set were nearly identical but where the two sets differed both by MLST and ABC typing. MLST therefore confirms the existing view of C. albicans strain carriage. Microvariation, evidenced as small differences between MLST types, resulted in most instances from a loss of heterozygosity at one or more of the sequenced loci. Among isolate sets that showed major strain type differences, some isolates could be excluded as likely examples of handling errors during storage. However, for a minority of isolates, intermittent differences in ABC type for tightly clustered MLST types and intermittent appearances of MTL homozygosity lead us to propose that some C. albicans isolates, or all isolates under yet-to-be-determined conditions, maintain a high level of genetic diversity by mechanisms such as recombination, gene conversion, or chromosomal ploidy change.
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