ArticleJournal of clinical microbiology2006
Molecular epidemiology of rotavirus diarrhea among children and adults in Nepal: detection of G12 strains with P[6] or P[8] and a G11P[25] strain.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Etiology of diarrhea in older children, adolescents and adults: a systematic review.PLoS neglected tropical diseases · 2010Pooled it
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- Factors contributing to the frequent interspecies transmission of G4P[6]Microbial genomics · 2026Article
- Pediatric Rotavirus A Infection Among 337,019 Participants Within Asia: A Pan-Asian Systematic Review and Meta-Analysis.Journal of tropical medicine · 2026Review
- Epidemiology and clinical features of Rotavirus infection among children in Rawalpindi, Pakistan.PloS one · 2025Article
- Diversity of Rotavirus Strains in Children; Results From a Community-Based Study in Nepal.Frontiers in medicine · 2021Article
- Article
- Outbreak associated with Rotavirus G11,P[25] in Korea in 2018.Infection & chemotherapy · 2020Article
- Diversity of rotavirus genotypes circulating in children < 5 years of age hospitalized for acute gastroenteritis in India from 2005 to 2016: analysis of temporal and regional genotype variation.BMC infectious diseases · 2020Article
- Surveillance of Human Rotavirus in Wuhan, China (2011-2019): Predominance of G9P[8] and Emergence of G12.Pathogens (Basel, Switzerland) · 2020Article
- Co-infection with Campylobacter and rotavirus in less than 5 year old children with acute gastroenteritis in Nepal during 2017-2018.BMC pediatrics · 2020Article
- Acute gastroenteritis associated with Rotavirus A among children less than 5 years of age in Nepal.BMC infectious diseases · 2019Article
- Co-Infection by Waterborne Enteric Viruses in Children with Gastroenteritis in Nepal.Healthcare (Basel, Switzerland) · 2019Article
- Distribution of Rotavirus Genotypes Ccirculating in Ahvaz, Iran in 2016Iranian biomedical journal · 2018Article
- Pathogen-Specific Burden of Outpatient Diarrhea in Infants in Nepal: A Multisite Prospective Case-Control Study.Journal of the Pediatric Infectious Diseases Society · 2017Article
- Molecular epidemiology of Rotavirus causing diarrhea among children less than five years of age visiting national level children hospitals, Nepal.BMC pediatrics · 2017Article
- Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents.Molecular biology and evolution · 2015Article
- A Prospective Hospital-based Surveillance to Estimate Rotavirus Disease Burden in Bhutanese Children under 5 Years of Age.Tropical medicine and health · 2015Article
- Whole Genomic Analysis of Human G12P[6] and G12P[8] Rotavirus Strains that Have Emerged in Myanmar.PloS one · 2015Article
- Genetic analysis of G12P[8] rotaviruses detected in the largest U.S. G12 genotype outbreak on record.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In anticipation of a rotavirus vaccine in Nepal, this study was undertaken to determine the distribution of the G and P serotypes and electropherotypes of rotaviruses in order to examine if there is any emerging serotype or unusual strain circulating in children and adults in Nepal. Of 1,315 diarrheal stool specimens, rotavirus was detected by an enzyme-linked immunosorbent assay in 116 (17%) of 666 patients less than 5 years of age, in 18 (7%) of 260 patients 5 to 14 years of age, and in 19 (5%) of 358 patients 15 years of age and older. Approximately 75% of rotavirus diarrhea occurred in children less than 5 years of age. Approximately 70% of rotaviruses found in each of the three age groups belonged to serotype G1P[8]. Interestingly, there were 29 (20%) G12 rotaviruses carrying either P[8] or P[6] and one (0.7%) G11 rotavirus carrying an unusual P[25] genotype. RNA polyacrylamide gel electrophoresis discriminated 19 strains (electropherotypes), among which there were three codominant strains carrying G1P[8] and long RNA patterns. Five electropherotypes were discriminated among G12 rotaviruses, all of which had long RNA patterns. The fact that 20% of rotaviruses were G12 strains carrying either P[8] or P[6] and had multiple electropherotypes suggest that G12 strains are not more rare strains but that they pose an emerging challenge to current and future vaccines. The presence of multiple strains as defined by electropherotypes suggests the richness of the rotavirus gene pool in Nepal, where unusual strains may continue to emerge.
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