ArticleJournal of clinical microbiology2006
Blood culture contamination in Tanzania, Malawi, and the United States: a microbiological tale of three cities.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01413555 (Multicenter Implementation of a Quality Improvement Program to Reduce Blood Culture Contamination in the Emergency Department), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Implementation of a Quality Improvement Program to Reduce Blood Culture Contamination in the Emergency Department
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prevalence of complications of male circumcision in Anglophone Africa: a systematic review.BMC urology · 2007Pooled it
- Blood culture surveillance in a secondary care hospital in Benin: epidemiology of bloodstream infection pathogens and antimicrobial resistance.BMC infectious diseases · 2022Article
- Underutilization and Quality Gaps in Blood Culture Processing in Public Hospitals of Peru.The American journal of tropical medicine and hygiene · 2021Article
- Ecology of Bloodstream Infections and Temporal Trends of Their Antibiograms with Respect to Source and Duration of Incubation: A 5-Year Retrospective Observational Analysis.Journal of laboratory physicians · 2020Article
- Risk Factors for Neonatal Sepsis and Method for Reduction of Blood Culture Contamination.Malawi medical journal : the journal of Medical Association of Malawi · 2015Article
- Article
- Cost analysis of strategies to reduce blood culture contamination in the emergency department: sterile collection kits and phlebotomy teams.Infection control and hospital epidemiology · 2014Article
- Quality assurance in blood culture: A retrospective study of blood culture contamination rate in a tertiary hospital in Nigeria.Nigerian medical journal : journal of the Nigeria Medical Association · 2014Article
- Reducing blood culture contamination in community hospital emergency departments: a multicenter evaluation of a quality improvement intervention.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2014Article
- Reducing blood culture contamination in the emergency department: an interrupted time series quality improvement study.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2013Article
- Species-driven interpretation guidelines in case of a single-sampling strategy for blood culture.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- Impact of blood cultures drawn by phlebotomy on contamination rates and health care costs in a hospital emergency department.Journal of clinical microbiology · 2009Article
- Isopropyl alcohol compared with isopropyl alcohol plus povidone-iodine as skin preparation for prevention of blood culture contamination.Journal of clinical microbiology · 2009Article
- Ethical and practical consideration of women choosing cesarean section deliveries without "medical indication" in developing countries.Croatian medical journal · 2007Review
- Bloodstream infections and trends of antimicrobial sensitivity patterns at Port Blair.Journal of laboratory physiciansArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted retrospective, comparative analyses of contamination rates for cultures of blood obtained in the emergency rooms of Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania; Lilongwe Central Hospital (LCH) in central Malawi; and the Duke University Medical Center (DUMC) in the United States. None of the emergency room patients had indwelling intravascular devices at the time that the blood samples for cultures were obtained. In addition, we reviewed the contamination rates for a cohort of patients already hospitalized in the DUMC inpatient medical service, most of whom had indwelling intravascular devices. The bloodstream infection rates among the patients at MNH (n=513) and LCH (n=486) were similar (approximately 28%); the contamination rates at the two hospitals were 1.3% (7/513) and 0.8% (4/486), respectively. Of 54 microorganisms isolated from cultures of blood collected in the DUMC emergency room, 26 (48%) were identified as skin contaminants. Cultures of blood collected in the DUMC emergency room were significantly more likely to yield growth of contaminants than the cultures of blood collected in the emergency rooms at MNH and LCH combined (26/332 versus 11/1,003; P<0.0001) or collected in the DUMC inpatient medical service (26/332 versus 7/283; P<0.01). For the MNH and LCH blood cultures, lower contamination rates were observed when skin was disinfected with isopropyl alcohol plus tincture of iodine rather than isopropyl alcohol plus povidone-iodine. In conclusion, blood culture contamination was minimized in sub-Saharan African hospitals with substantially limited resources through scrupulous attention to aseptic skin cleansing and improved venipuncture techniques. Application of these principles when blood samples for culture are obtained in U.S. hospital emergency rooms should help mitigate blood culture contamination rates and the unnecessary microbiology workup of skin contaminants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.