Evidence map›Paper›PMID 17020945›Full record

ArticleJournal of virology2006

Proviral progeny of heterodimeric virions reveal a high crossover rate for human immunodeficiency virus type 2.

Sayandip Mukherjee, Hui-Ling Rose Lee, Yacov Ron, Joseph P Dougherty

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sayandip MukherjeeDepartment of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Hui-Ling Rose Lee
Yacov Ron
Joseph P Dougherty

Funding

DETERMINATION OF RETROVIRUS MUTATION RATESR01CA050777 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI DOUGHERTY, JOSEPH · 1995 to 2003
$1.0M
A virus/cell based assay for discovery of anti-HIV drugsR42AI051910 · NIAID · PTC THERAPEUTICS, INC. · PI DOUGHERTY, JOSEPH · 2003 to 2004
$558k
A virus/cell based assay for discovery of anti-HIV drugsR41AI051910 · NIAID · PTC THERAPEUTICS, INC. · PI DOUGHERTY, JOSEPH · 2002 to 2002
$127k
DETERMINATION OF RETROVIRUS MUTATION RATESR29CA050777 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI DOUGHERTY, JOSEPH · 1989 to 1993
–
NCI NIH HHS CA50777NIAID NIH HHS AI51910NIAID NIH HHS R41 AI051910NIAID NIH HHS R42 AI051910
6 · The paper itself

Abstract

Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS in humans, exhibits a very high rate of recombination. Bearing in mind the significant epidemiological and clinical contrast between HIV-2 and HIV-1 as well as the critical role that recombination plays in viral evolution, we examined the nature of HIV-2 recombination. Towards this end, a strategy was devised to measure the rate of crossover of HIV-2 by evaluating recombinant progeny produced exclusively by heterodimeric virions. The results showed that HIV-2 exhibits a crossover rate similar to that of HIV-1 and murine leukemia virus, indicating that the extremely high rate of crossover is a common retroviral feature.

Indexed as

Evolution, MolecularCrossing Over, GeneticGenetic VectorsHIV-2Models, GeneticProvirusesVirion

Identifiers

PMID17020945
PMCPMC1676297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.