ArticleNucleic acids research2006
Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- PIWI proximity proteome reveals Set1-mediated piRNA biogenesis for transposon silencing at telomeres.EMBO reports · 2026Article
- TAR30, a homolog of the canonical plant TTTAGGG telomeric repeat, is enriched in the proximal chromosome regions of peanut (Arachis hypogaea L.).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Rapid evolution at the Drosophila telomere: transposable element dynamics at an intrinsically unstable locus.Genetics · 2021Article
- Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline.Epigenetics & chromatin · 2018Article
- Article
- Transposons play an important role in the evolution and diversification of centromeres among closely related species.Frontiers in plant science · 2015Article
- Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the drosophila germline.PLoS genetics · 2014Article
- The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART.Mobile DNA · 2013Article
- Retrotransposons at Drosophila telomeres: host domestication of a selfish element for the maintenance of genome integrity.Biochimica et biophysica acta · 2012Review
- A highly conserved, small LTR retrotransposon that preferentially targets genes in grass genomes.PloS one · 2012Article
- Retrotransposons that maintain chromosome ends.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons.Nucleic acids research · 2011Article
- Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job.Mobile genetic elements · 2011Article
- Differential maintenance of DNA sequences in telomeric and centromeric heterochromatin.Genetics · 2011Article
- Evolution of diverse mechanisms for protecting chromosome ends by Drosophila TART telomere retrotransposons.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Evolution of species-specific promoter-associated mechanisms for protecting chromosome ends by Drosophila Het-A telomeric transposons.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- rasiRNA pathway controls antisense expression of Drosophila telomeric retrotransposons in the nucleus.Nucleic acids research · 2009Article
- Regulation of telomere length in Drosophila.Cytogenetic and genome research · 2008Review
- Transcription and activation under environmental stress of the complex telomeric repeats of Chironomus thummi.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Transcriptional activity of the telomeric retrotransposon HeT-A in Drosophila melanogaster is stimulated as a consequence of subterminal deficiencies at homologous and nonhomologous telomeres.Molecular and cellular biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila non-long terminal repeat (non-LTR) retrotransposons TART and HeT-A specifically retrotranspose to chromosome ends to maintain Drosophila telomeric DNA. Relatively little is known, though, about the regulation of their expression and their retrotransposition to telomeres. We have used rapid amplification of cDNA ends (RACE) to identify multiple transcription initiation and polyadenylation sites for sense and antisense transcripts of three subfamilies of TART elements in Drosophila melanogaster. These results are consistent with the production of an array of TART transcripts. In contrast to other Drosophila non-LTR elements, a major initiation site for sense transcripts was mapped near the 3' end of the TART 5'-untranslated region (5'-UTR), rather than at the start of the 5'-UTR. A sequence overlapping this sense start site contains a good match to an initiator consensus for the transcription start sites of Drosophila LTR retrotransposons. Interestingly, analysis of 5' RACE products for antisense transcripts and the GenBank EST database revealed that TART antisense transcripts contain multiple introns. Our results highlight differences between transcription of TART and of other Drosophila non-LTR elements and they provide a foundation for testing the relationship between exceptional aspects of TART transcription and TART's specialized role at telomeres.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.