ArticleCerebrospinal fluid research2006
Biomarkers in chronic adult hydrocephalus.
Article in Cerebrospinal fluid research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Exploring causal correlations of inflammatory biomarkers in idiopathic normal-pressure hydrocephalus: insights from bidirectional Mendelian randomization analysis.Frontiers in aging neuroscience · 2024Article
- CSF levels of myelin basic protein in pediatric patients with ventriculoperitoneal shunt infection.Central-European journal of immunology · 2020Article
- Does Phase-Contrast Imaging through the Cerebral Aqueduct Predict the Outcome of Lumbar CSF Drainage or Shunt Surgery in Patients with Suspected Adult Hydrocephalus?AJNR. American journal of neuroradiology · 2018Article
- A novel approach for characterizing variations in serum peptides in rheumatic heart disease.The Indian journal of medical research · 2017Article
- Nonsurgical therapy for hydrocephalus: a comprehensive and critical review.Fluids and barriers of the CNS · 2016Review
- Article
- Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.Current medicinal chemistry · 2015Review
- Long-term hydrocephalus alters the cytoarchitecture of the adult subventricular zone.Experimental neurology · 2014Article
- New concepts in the pathogenesis of hydrocephalus.Translational pediatrics · 2014Review
- The 1H NMR profile of healthy dog cerebrospinal fluid.PloS one · 2013Article
- Comparison of cerebrospinal fluid biomarkers between idiopathic normal pressure hydrocephalus and subarachnoid hemorrhage-induced chronic hydrocephalus: a pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Proteome analysis of human cerebrospinal fluid as a diagnostic biomarker in patients with meningioma.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Increased Vascular Endothelial Growth Factor in the Ventricular Cerebrospinal Fluid as a Predictive Marker for Subsequent Ventriculoperitoneal Shunt Infection : A Comparison Study among Hydrocephalic Patients.Journal of Korean Neurosurgical Society · 2012Article
- Reactive astrocytosis in feline neonatal hydrocephalus: acute, chronic, and shunt-induced changes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Reduced CSF turnover and decreased ventricular Aβ42 levels are related.BMC neuroscience · 2011Article
- Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus.International journal of Alzheimer's disease · 2011Article
- Intraventricular infusion of hyperosmolar dextran induces hydrocephalus: a novel animal model of hydrocephalus.Cerebrospinal fluid research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Awareness of the importance of chronic adult hydrocephalus has been raised again with the recent emergence of epidemiological studies. It is estimated that between 5 and 10% of patients suffering from dementia might, in fact, have chronic hydrocephalus. Although, surgical diversion of the cerebrospinal fluid (CSF) represents the only known procedure able to treat the symptoms of this condition, the selection of surgical patients has always been problematic. In the last 40 years, we have become wiser in using appropriate diagnostic tests for the selection of these patients; however, the area of biological markers has so far been overlooked in this condition, in contrast to that for other neurodegenerative disorders and dementias. Biomarkers are biological substances that may be used to indicate either the onset or the presence, and the progression of a clinical condition, being closely linked to its pathophysiology. In such a setting they might assist in the more appropriate selection of patients for shunt surgery. In this article, we have reviewed research carried out in the last 25 years regarding the identification of serum and CSF biomarkers for chronic hydrocephalus, discussed the potential for each one, and finally discussed the limitations for use, as well as future directions and possibilities in this field. It is concluded that tumour-necrosis factor, tau protein, lactate, sulfatide and neurofilament triple protein are the most promising CSF markers for chronic hydrocephalus. At present however, none of these meet the criteria required to justify a change clinical practice. In the future, collaborative multi-centre projects will be needed to obtain more substantial data that overcome the problems that arise from small individual and uncoordinated studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.