ArticleOrganic letters2006
Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold.
Article in Organic letters, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.ACS chemical biology · 2018Article
- Protein stabilization by tuning the steric restraint at the reverse turn.Chemical science · 2018Article
- A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis.ACS central science · 2016Article
- Engineering β-sheets employingChemical science · 2016Article
- Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.Organic & biomolecular chemistry · 2013Article
- Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres.Organic process research & development · 2012Article
- Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs.Organic letters · 2011Article
- Article
- Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.Nature structural & molecular biology · 2009Article
- Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn.Journal of medicinal chemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
[reaction: see text] A concise synthesis of a gramicidin S analogue with trisubstituted (E)-alkene dipeptide isostere (TEADI) replacements at both d-Phe-Pro positions was realized. Conformational analysis demonstrated that TEADIs can serve as type II beta-turn promoters in a cyclic scaffold and successfully mimic a proline residue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.