ArticlePhysics in medicine and biology2006
Rapid dual-injection single-scan 13N-ammonia PET for quantification of rest and stress myocardial blood flows.
Article in Physics in medicine and biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Technical evaluation of immediate back-to-back rest-stress positron emission tomography scanning withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Kinetic model-informed deep learning for multiplexed PET image separation.EJNMMI physics · 2024Article
- Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Multiparametric CardiacIEEE transactions on radiation and plasma medical sciences · 2020Article
- PET Parametric Imaging: Past, Present, and Future.IEEE transactions on radiation and plasma medical sciences · 2020Article
- Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy.EJNMMI physics · 2020Article
- Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique forCirculation. Cardiovascular imaging · 2020Article
- Single-scan rest/stress imaging: validation in a porcine model withEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Article
- Application of separable parameter space techniques to multi-tracer PET compartment modeling.Physics in medicine and biology · 2016Article
- Dual-tracer PET using generalized factor analysis of dynamic sequences.Molecular imaging and biology · 2013Article
- Single-scan dual-tracer FLT+FDG PET tumor characterization.Physics in medicine and biology · 2013Article
- Single-scan rest∕stress imaging (18)F-labeled flow tracers.Medical physics · 2012Article
- Ready for prime time? Dual tracer PET and SPECT imaging.American journal of nuclear medicine and molecular imaging · 2012Article
- Assessment of myocardial perfusion and function with PET and PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Review
- Rapid Multi-Tracer PET Tumor Imaging With F-FDG and Secondary Shorter-Lived Tracers.IEEE transactions on nuclear science · 2009Article
- Navigating beyond the 6th dimension: a challenge in the era of multi-parametric molecular imaging.European journal of nuclear medicine and molecular imaging · 2009Article
- Estimating myocardial perfusion from dynamic contrast-enhanced CMR with a model-independent deconvolution method.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2008Article
- Evaluation of rapid dual-tracer (62)Cu-PTSM + (62)Cu-ATSM PET in dogs with spontaneously occurring tumors.Physics in medicine and biology · 2008Article
Corrections and comments
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6 authors.
Funding
Abstract
Quantification of myocardial blood flows at rest and stress using 13N-ammonia PET is an established method; however, current techniques require a waiting period of about 1 h between scans. The objective of this study was to test a rapid dual-injection single-scan approach, where 13N-ammonia injections are administered 10 min apart during rest and adenosine stress. Dynamic PET data were acquired in six human subjects using imaging protocols that provided separate single-injection scans as gold standards. Rest and stress data were combined to emulate rapid dual-injection data so that the underlying activity from each injection was known exactly. Regional blood flow estimates were computed from the dual-injection data using two methods: background subtraction and combined modelling. The rapid dual-injection approach provided blood flow estimates very similar to the conventional single-injection standards. Rest blood flow estimates were affected very little by the dual-injection approach, and stress estimates correlated strongly with separate single-injection values (r=0.998, mean absolute difference=0.06 ml min-1 g-1). An actual rapid dual-injection scan was successfully acquired in one subject and further demonstrates feasibility of the method. This study with a limited dataset demonstrates that blood flow quantification can be obtained in only 20 min by the rapid dual-injection approach with accuracy similar to that of conventional separate rest and stress scans. The rapid dual-injection approach merits further development and additional evaluation for potential clinical use.
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