ArticleCancer research2006
High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances.
Article in Cancer research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed.
- Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951.Journal of neuro-oncology · 2011Trial
- LPPR5 Expression in Glioma Affects Growth, Vascular Architecture, and Sunitinib Resistance.International journal of molecular sciences · 2022Article
- High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates With Lower Survival.Frontiers in molecular biosciences · 2021Article
- Steroid receptor-associated and regulated protein is a biomarker in predicting the clinical outcome and treatment response in malignancies.Cancer reports (Hoboken, N.J.) · 2020Article
- MGSEA - a multivariate Gene set enrichment analysis.BMC bioinformatics · 2019Article
- Obstacles to Brain Tumor Therapy: Key ABC Transporters.International journal of molecular sciences · 2017Review
- Chromosomal Aberrations in Canine Gliomas Define Candidate Genes and Common Pathways in Dogs and Humans.Journal of neuropathology and experimental neurology · 2016Article
- Expression of ZFX gene correlated with the central features of the neoplastic phenotype in human brain tumors with distinct phenotypes.Advanced biomedical research · 2015Article
- DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.PloS one · 2015Article
- Mapping of the chromosomal amplification 1p21-22 in bladder cancer.BMC research notes · 2014Article
- Integrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer Metastasis.Cancer informatics · 2014Article
- Group sparse canonical correlation analysis for genomic data integration.BMC bioinformatics · 2013Article
- Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Genome-wide associations of signaling pathways in glioblastoma multiforme.BMC medical genomics · 2013Article
- Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-κB signaling pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15(+)/CalB(+) leukocytes.PloS one · 2013Article
- Module cover - a new approach to genotype-phenotype studies.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2013Article
- Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels.PloS one · 2013Article
- Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.PloS one · 2013Article
- Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Primary brain tumors are the fourth leading cause of cancer mortality in adults under the age of 54 years and the leading cause of cancer mortality in children in the United States. Therapy for the most common type of primary brain tumors, gliomas, remains suboptimal. The development of new and more effective treatments will likely require a better understanding of the biology of these tumors. Here, we show that use of the high-density 100K single-nucleotide polymorphism arrays in a large number of primary tumor samples allows for a much higher resolution survey of the glioma genome than has been previously reported in any tumor type. We not only confirmed alterations in genomic areas previously reported to be affected in gliomas, but we also refined the location of those sites and uncovered multiple, previously unknown regions that are affected by copy number alterations (amplifications, homozygous and heterozygous deletions) as well as allelic imbalances (loss of heterozygosity/gene conversions). The wealth of genomic data produced may allow for the development of a more rational molecular classification of gliomas and serve as an important starting point in the search for new molecular therapeutic targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.