ArticleRNA (New York, N.Y.)2006
Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- A screen for synthetic genetic interactions with the Saccharomyces cerevisiae hrq1ΔN allele.G3 (Bethesda, Md.) · 2025Article
- FAM207A acts as a novel and potential biomarker in lung adenocarcinoma and shapes the immunesuppressive tumor microenvironment.Clinical and experimental medicine · 2025Article
- Ribosome biogenesis factors-from names to functions.The EMBO journal · 2023Review
- Eukaryotic Ribosome assembly and Nucleocytoplasmic Transport.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The nucleolar protein SAHY1 is involved in pre-rRNA processing and normal plant growth.Plant physiology · 2021Article
- Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of theG3 (Bethesda, Md.) · 2020Article
- A Novel G-Quadruplex Binding Protein in Yeast-Slx9.Molecules (Basel, Switzerland) · 2019Article
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- Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response.The Journal of biological chemistry · 2015Article
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- Ribosome biogenesis in the yeast Saccharomyces cerevisiae.Genetics · 2013Review
- The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP.RNA (New York, N.Y.) · 2013Article
- Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae.Nucleic acids research · 2013Article
- Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.PLoS genetics · 2012Article
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- Article
- Rational extension of the ribosome biogenesis pathway using network-guided genetics.PLoS biology · 2009Article
- A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor.Genetics · 2009Article
- The small subunit processome in ribosome biogenesis—progress and prospects.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slx9p (Ygr081cp) is a nonessential yeast protein previously linked genetically with the DNA helicase Sgs1p. Here we report that Slx9p is involved in ribosome biogenesis in the yeast Saccharomyces cerevisiae. Deletion of SLX9 results in a mild growth defect and a reduction in the level of 18S rRNA. Co-immunoprecipitation experiments showed that Slx9p is associated with 35S, 23S, and 20S pre-rRNA, as well as U3 snoRNA and, thus, is a bona fide component of pre-ribosomes. The most striking effects on pre-rRNA processing resulting from deletion of SLX9 is the accumulation of the mutually exclusive 21S and 27SA2 pre-rRNA. Furthermore, deletion of SLX9 is synthetically lethal with mutations in Rrp5p that block cleavage at either site A2 or A3. We conclude that Slx9p has a unique role in the processing events responsible for separating the 66S and 43S pre-ribosomal particles. Interestingly, homologs of Slx9p were found only in other yeast species, indicating that the protein has been considerably less well conserved during evolution than the majority of trans-acting processing factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.