ArticleRNA (New York, N.Y.)2006
Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Aptamer-Based Detection of Foot-and-Mouth Disease Virus Using Single-Stranded DNA Probe.Applied biochemistry and biotechnology · 2025Article
- Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication.Communications biology · 2022Article
- Aptamer-based diagnostic and therapeutic approaches in animals: Current potential and challenges.Saudi journal of biological sciences · 2021Review
- Aptamers in Therapeutics.Journal of clinical and diagnostic research : JCDR · 2016Review
- Article
- Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.The Journal of general virology · 2014Article
- Article
- IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?The Journal of investigative dermatology · 2014Article
- An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.PloS one · 2013Article
- Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity.Journal of virology · 2012Article
- Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.PloS one · 2010Article
- Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex.Nucleic acids research · 2009Article
- Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein.BMC structural biology · 2009Article
- Production and characterization of RNA aptamers specific for amyloid fibril epitopes.The Journal of biological chemistry · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foot-and-mouth disease virus causes a highly contagious disease of agricultural livestock and is of enormous economic importance. Replication of the RNA genome of the virus, via negative strand intermediates, involves an RNA-dependent RNA polymerase (3Dpol). RNA aptamers specific to this enzyme have been selected and characterized. Some of these molecules inhibit enzymatic activity in vitro, with IC50 values of <20 nM and Ki values of 18-75 nM. Two of these show similarity, both with each other and with regions of the viral genome. Furthermore, truncated versions of one of the aptamers have been used to define the parts of the molecule responsible for its inhibitory activity.
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