ArticleBMC gastroenterology2006
Helicobacter pylori genotypes identified in gastric biopsy specimens from Jordanian patients.
Article in BMC gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Allelic Variation ofMicroorganisms · 2025Article
- Assessment ofHeliyon · 2024Article
- A Genetic and Immunohistochemical Analysis of Helicobacter pylori Phenotypes and p27 Expression in Adenocarcinoma Patients in Jordan.Journal of epidemiology and global health · 2023Article
- Detection of Helicobacter pylori and its virulence genes (cagA, dupA, and vacA) among patients with gastroduodenal diseases in Chris Hani Baragwanath Academic Hospital, South Africa.BMC gastroenterology · 2019Article
- Prevalence ofPathogens (Basel, Switzerland) · 2019Article
- Trends and Risk Factors of Gastric Cancer in Iran (2005-2010).International journal of preventive medicine · 2019Article
- Analysis ofGastroenterology research · 2018Article
- Prevalence of CagA and antimicrobial sensitivity ofInfectious agents and cancer · 2018Article
- Article
- Analysis ofMicrobiology insights · 2016Article
- Prevalence of Helicobacter pylori vacA, cagA, and iceA Genotypes in Cuban Patients with Upper Gastrointestinal Diseases.BioMed research international · 2015Article
- Prevalence and distribution of Helicobacter pylori cagA and vacA genotypes in the Moroccan population with gastric disease.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Helicobacter pylori and gastric cancer in the Middle East: a new enigma?World journal of gastroenterology · 2010Review
- Prevalence of Helicobacter pylori vacA, cagA, iceA and oipA genotypes in Tunisian patients.Annals of clinical microbiology and antimicrobials · 2010Article
- Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world.Journal of clinical microbiology · 2010Article
- Analysis of Helicobacter pylori genotypes in Afghani and Iranian isolates.Polish journal of microbiology · 2010Article
- The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Distribution of Helicobacter pylori cagA, cagE, oipA and vacA in different major ethnic groups in Tehran, Iran.Journal of gastroenterology and hepatology · 2009Article
- Helicobacter pylori genotyping and sequencing using paraffin-embedded biopsies from residents of colombian areas with contrasting gastric cancer risks.Helicobacter · 2008Article
- cagA gene and protein status among Iranian Helicobacter pylori strains.Digestive diseases and sciences · 2008Article
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4 authors.
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Abstract
backgroundThe genetic diversity of Helicobacter pylori can be analyzed at two different levels: the genomic variation between strains originating from different individuals, and the variation in bacterial populations within an individual host. We reported for the first time the H. pylori genotypes in Jordanian patients with gastrointestinal diseases.
methodsUpper endoscopy was performed on 250 patients with symptoms of gastrointestinal diseases. Multiple gastric biopsy specimens were taken from the antrum. All the biopsies were tested by PCR for the H. pylori virulence genes vacA, cagA, and iceA, and 151 were tested by histology.
resultsThe biopsies positive for H. pylori by PCR were 110/250 (44%), and by histology 117/151 (77.5%), and these results were highly associated (P < 0.02). Analyses of virulence genes revealed that iceA2 (73.6%) was the predominant genotype, the vacAs2 allele was more frequently identified than the vacAs1 allele, while the cagA genotype was low (26.4%). The presence of certain genotypes might be associated with each other, but the presence of certain genotypes was not significantly associated with the age, or gender of the patient.
conclusionThe results illustrate the geographic nature of the genetic diversity of H. pylori, as the identified genotypes are similar to those reported in neighboring countries. This study provides a baseline data of H. pylori genotypes identified in gastric biopsy specimens from Jordan, serving as a powerful epidemiological tool for prospective investigations to better understand the genetic diversity of this pathogen.
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